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Article
Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent due in part to the complexity of this disease and variation in study design. Even in cases in which individual microbi...
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Article
Impact of rise and fall phases of shear on platelet activation and aggregation using microfluidics
Blood flow disorders are often the result of the non-physiological narrowing of blood arteries caused by atherosclerosis and thrombus. The blood then proceeds through rising-peak-decreasing phases as it passes...
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Article
Open AccessRoles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance
Despite advances in therapeutic strategies, resistance to immunotherapy and the off-target effects of targeted therapy have significantly weakened the benefits for patients with melanoma.
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Article
Open AccessAnalysis of fecal microbiome and metabolome changes in goats with pregnant toxemia
Pregnancy toxemia is a common disease, which occurs in older does that are pregnant with multiple lambs in the third trimester. Most of the sick goats die within a few days, which can seriously impact the econ...
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Chapter and Conference Paper
AttnOD: An Attention-Based OD Prediction Model with Adaptive Graph Convolution
In recent years, with the continuous growth of traffic scale, the prediction of passenger demand has become an important problem. However, many of the previous methods only considered the passenger flow in a r...
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Article
Cordycepin Inhibits Pathological High Shear-Induced Platelet Aggregation, Activation, and Phosphatidylserine Exposure by Regulating the Phosphorylation of Akt Protein
Cordycepin can effectively inhibit adenosine diphosphate-induced platelet aggregation; however, the inhibitory effect on shear-induced platelet aggregation is not known. Pathological high shear stress is an im...
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Article
Open AccessRNA-based amplicon sequencing is ineffective in measuring metabolic activity in environmental microbial communities
Characterization of microbial activity is essential to the understanding of the basic biology of microbial communities, as the function of a microbiome is defined by its biochemically active (“viable”) communi...
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Article
Experimental study on pressure stimulated current response characteristics during damage evolution of water-bearing coal samples
The damage and rupture behavior of water-bearing coal induced by coal mining disturbance can lead to large-scale rock engineering instability and engineering geological disasters. In order to study the influen...
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Article
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
For decades, variability in clinical efficacy of the widely used inflammatory bowel disease (IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and inactivation by gut mic...
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Article
Changes in the aroma characteristics during the different processes of dry Cabernet Sauvignon wine production
Wine contains a multitude of volatile and non-volatile compounds. The sensory characteristics of wine are strongly influenced by the volatile aromas. In this study, we used headspace solid-phase micro-extracti...
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Article
Infrared Radiation and Acoustic Emission of Damage Evolution and Failure Precursory for Water-Bearing Coal
The instability and failure of water-bearing coal mass can lead to serious coal–rock dynamic disasters, such as mine water inrush. It brings severe challenges to the safety produce during coal mining activitie...
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Article
Downregulation of the paired box gene 3 inhibits the progression of skin cutaneous melanoma by inhibiting c-MET tyrosine kinase
The PAX3 (paired box gene 3) gene is highly expressed in several cancer types. However, its underlying mechanism of action in skin cutaneous melanoma (SKCM) remains unknown.
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Article
Open Accessα-Enolase inhibits apoptosis and promotes cell invasion and proliferation of skin cutaneous melanoma
The glycolytic enzyme, α-Enolase (ENO1), catalyzes the production of phosphoenolpyruvate from 2-phosphoglycerate, thereby enhancing glycolysis and contributing to tumor progression. In the present study, we ai...
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Article
A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria
Members of the human gut microbiome enzymatically process many bioactive molecules in the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic or reductive in nature. He...
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Article
Root-secreted bitter triterpene modulates the rhizosphere microbiota to improve plant fitness
Underground microbial ecosystems have profound impacts on plant health1–5. Recently, essential roles have been shown for plant specialized metabolites in sha** the rhizosphere microbiome6–9. However, the potent...
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Article
Mortar Designed from Red Mud with Iron Tailings and Moulded by 3D Printing
A specific mortar material (abbreviated as RFT) was designed from industrial solid wastes, such as red mud, fly ash, and iron tailings. It was mainly developed for 3D printing in this work. Mechanical properti...
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Article
Discovery of bioactive microbial gene products in inflammatory bowel disease
Microbial communities and their associated bioactive compounds1–3 are often disrupted in conditions such as the inflammatory bowel diseases (IBD)4. However, even in well-characterized environments (for example, t...
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Article
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 cells). We previously reported that...
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Chapter and Conference Paper
Reversible Data Hiding Based on Multiple Strategies
A reversible data hiding method based on multiple strategies is proposed in this method. To fully exploit strong correlations among pixels, the third maximum pixel is used for predicting the second maximum pix...
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Article
Open AccessWhole microbial community viability is not quantitatively reflected by propidium monoazide sequencing approach
High-throughput sequencing provides a powerful window into the structural and functional profiling of microbial communities, but it is unable to characterize only the viable portion of microbial communities at...
