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Article
Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent due in part to the complexity of this disease and variation in study design. Even in cases in which individual microbi...
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Article
Open AccessRNA-based amplicon sequencing is ineffective in measuring metabolic activity in environmental microbial communities
Characterization of microbial activity is essential to the understanding of the basic biology of microbial communities, as the function of a microbiome is defined by its biochemically active (“viable”) communi...
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Article
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
For decades, variability in clinical efficacy of the widely used inflammatory bowel disease (IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and inactivation by gut mic...
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Article
Changes in the aroma characteristics during the different processes of dry Cabernet Sauvignon wine production
Wine contains a multitude of volatile and non-volatile compounds. The sensory characteristics of wine are strongly influenced by the volatile aromas. In this study, we used headspace solid-phase micro-extracti...
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Article
A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria
Members of the human gut microbiome enzymatically process many bioactive molecules in the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic or reductive in nature. He...
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Article
Root-secreted bitter triterpene modulates the rhizosphere microbiota to improve plant fitness
Underground microbial ecosystems have profound impacts on plant health1–5. Recently, essential roles have been shown for plant specialized metabolites in sha** the rhizosphere microbiome6–9. However, the potent...
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Article
Discovery of bioactive microbial gene products in inflammatory bowel disease
Microbial communities and their associated bioactive compounds1–3 are often disrupted in conditions such as the inflammatory bowel diseases (IBD)4. However, even in well-characterized environments (for example, t...
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Article
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 cells). We previously reported that...
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Article
Open AccessWhole microbial community viability is not quantitatively reflected by propidium monoazide sequencing approach
High-throughput sequencing provides a powerful window into the structural and functional profiling of microbial communities, but it is unable to characterize only the viable portion of microbial communities at...
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Article
Measurement and Correction of Interface Shear Stiffness between Slab and Base for Concrete Pavement
Interface parameters could affect the adhesion and durability performance of cement concrete pavements. In order to improve the pavement performance, the interface shear stiffness between the slab and the base...
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Article
Fiber-reinforced Mechanism and Mechanical Performance of Composite Fibers Reinforced Concrete
To understand the enhancing effect and fiber-reinforced mechanism of composite fibers reinforced cement concrete, the influences of composite fibers on micro-cracks and the distribution of composite fibers wer...
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Article
Open AccessGeneration of tooth–periodontium complex structures using high-odontogenic potential dental epithelium derived from mouse embryonic stem cells
A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. However, few studies have reported the regeneration of to...
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Article
Retraction Note to: Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson’s disease by bioinformatics
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Article
RETRACTED ARTICLE: Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson’s disease by bioinformatics
This study aimed to explore the underlying molecular mechanisms of idiopathic Parkinson’s disease (IPD) by bioinformatics analysis. Gene expression profile GSE34516 was download...
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Article
Genomic analyses provide insights into the history of tomato breeding
Sanwen Huang and colleagues report a comprehensive analysis of genetic variation in tomato based on the genome sequencing of 360 distinct accessions. The work provides insights into the history of tomato domes...
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Article
PDEA-coated magnetic nanoparticles for gene delivery to Hep G2 cells
Poly(2-(diethylamino)ethyl methacrylate) coated magnetic nanoparticles (PDEA-MNPs) were synthesized as a new gene nanocarrier to delivery plasmids (pEGFPN1 and pRL-TK) into human hepatoma (Hep G2) cells. The P...
