1,539 Result(s)
within
**an-long Zhang
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Article
Remote site-selective arene C–H functionalization enabled by N-heterocyclic carbene organocatalysis
Catalytic site-selective functionalization of distal C–H bonds represents a formidable challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic C(sp2)–H bonds remains largely...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Surface diffraction beamline at the SSRF
BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5 × 1012 photons/s at 10 keV and a beam size of 160 µm × 80 µm at the sample site. It is dedicated t...
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Open AccessAssessment of the influence of levees along Yangtze River on Oncomelania hupensis, the intermediate host of Schistosoma japonicum
Oncomelania hupensis is the exclusive intermediate host of Schistosoma japonicum in China. Snail control is an essential component of schistosomiasis elimination programme. With 70 years of continuous efforts, th...
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Boosting alkaline hydrogen evolution via spontaneous built-in electric field
The electrochemical reaction rate strongly depends on the pH of the solution and the relatively sluggish alkaline hydrogen evolution reaction (HER) process, attributed to alterations in the type of proton dono...
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Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour phenotype h...
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Vagus nerve electrical stimulation in the recovery of upper limb motor functional impairment after ischemic stroke
Ischemic stroke (IS) is characterized by high mortality, disability rates, and a high risk of recurrence. Motor dysfunction, such as limb hemiparesis, dysphagia, auditory disorders, and speech disorders, usual...
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The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets
Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes with high morbidity and mortality. Ferroptosis is a form of programmed cell death (PCD), is characterized by iron overloa...
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Open AccessSearch for central exclusive production of top quark pairs in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with tagged protons
A search for the central exclusive production of top quark-antiquark pairs ( t t ...
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The long-term efficacy of eltrombopag in children with immune thrombocytopenia
Immune thrombocytopenia (ITP) is the most common autoimmune disorder characterized by decreased platelet counts and impaired platelet production. Eltrombopag has been demonstrated to be safe and effective for ...
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Develo** Estimation Equations for the Cerchar Abrasivity Index of Rocks Applicable to TBM Tunnels
Rock abrasivity plays an important role in the machine design, construction scheduling, and budgeting of TBM projects. Establishing several faster and simpler estimation equations for the Cerchar Abrasivity In...
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Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have obvious advantages over MSC therapy. But the strong procoagulant properties of MSC-EVs pose a potential risk of thromboembolism, an issue tha...
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Role of inclination angle on columnar-to-equiaxed transition in the eutectic Al-5Mg-2Si alloy fabricated by laser powder bed fusion
In this study, the effect of inclination angles relative to the building direction in the additively manufactured eutectic Al-5Mg-2Si alloy was investigated through the laser powder bed fusion (LPBF). The micr...
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From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine **aoyaosan
The hippocampus is one of the most commonly studied brain regions in the context of depression. The volume of the hippocampus is significantly reduced in patients with depression, which severely disrupts hippo...
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Prediction on compression indicators of clay soils using XGBoost with Bayesian optimization
The determination of the compressibility of clay soils is a major concern during the design and construction of geotechnical engineering projects. Directly acquiring precise values of compression indicators fr...
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Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Open AccessAn integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs
Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, imp...
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One-neutron strip** process in the 209Bi(6Li, 5Li)210Bi* reaction reaction
One-neutron strip** process between \(^{6}\) 6 ...
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Open AccessSiglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia
Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiologic...
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Ultrahigh strength and uniform corrosion in Zn-Li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications
Zn-Li合金由于具备较高力学性能和良好的生物相容性，因此认为其在骨科植入物的应用领域具备广阔的发展前景。然而，这类锌合金中存在大量的第二相颗粒，在微电偶对作用下发生严重的局部降解，不利于该合金在人体组织愈合过程中力学的完整性。在本研究中，我们在3 GPa，375°C下制备的过饱和固溶Zn-xLi (x = 0.3, 0.5, 0.7; wt%)合金具备超高**度、均匀腐蚀、良好的细胞相容性和有效的抗菌能力等优点。在...
