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Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Article
Open AccessLeptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia
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Open AccessAdvancing skeletal health and disease research with single-cell RNA sequencing
Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited understanding of the underlying pathological processes at the cellu...
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Open AccessPhysical frailty, genetic predisposition, and incident dementia: a large prospective cohort study
Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical f...
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Article
Open AccessCirc-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9
CircRNAs are covalently closed, single-stranded RNA that form continuous loops and play a crucial role in the initiation and progression of tumors. Cancer stem cells (CSCs) are indispensable for cancer develop...
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Open AccessStructural mechanism of voltage-gated sodium channel slow inactivation
Voltage-gated sodium (NaV) channels mediate a plethora of electrical activities. NaV channels govern cellular excitability in response to depolarizing stimuli. Inactivation is an intrinsic property of NaV channel...
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Article
Open AccessAltered mucosal bacteria and metabolomics in patients with Peutz–Jeghers syndrome
Peutz–Jeghers syndrome (PJS) is a rare genetic disorder characterized by the development of pigmented spots, gastrointestinal polyps and increased susceptibility to cancers. Currently, most studies have invest...
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Open AccessOrigin of shear induced ‘catching bonds’ on half Heusler thermoelectric compounds XFeSb (X = Nb, Ta) and SnNiY (Y = Ti, Zr, Hf)
Half Heusler materials exhibit excellent thermoelectric and mechanical properties, rendering them potential candidates for advanced thermoelectric devices. Currently, the developments on interrelated devices a...
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Open AccessImmune persistence after different polio sequential immunization schedules in Chinese infants
Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented s...
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Open AccessLiquid lens based holographic camera for real 3D scene hologram acquisition using end-to-end physical model-driven network
With the development of artificial intelligence, neural network provides unique opportunities for holography, such as high fidelity and dynamic calculation. How to obtain real 3D scene and generate high fideli...
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Open AccessIP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway
Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...
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Open AccessNetwork pharmacology-based strategy to investigate the mechanisms of artemisinin in treating primary Sjögren’s syndrome
The study aimed to explore the mechanism of artemisinin in treating primary Sjögren’s syndrome (pSS) based on network pharmacology and experimental validation.
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Open AccessSurgical outcomes and perioperative risk factors of patients with interstitial lung disease after pulmonary resection
Patients of interstitial lung disease (ILD) combined with pulmonary lesions are increasingly common in clinical practice. Patients with ILD are at significantly higher risk for complications after pulmonary re...
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Open AccessNon-bone-derived exosomes: a new perspective on regulators of bone homeostasis
Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described; however, recent studies have shown that some non-bone-derived exoso...
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Open AccessGenetic susceptibility modifies the association of long-term air pollution exposure on Parkinson’s disease
Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into the role of inherited sensitivity. This study sought to explore the...
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Open AccessBiogeographic patterns of meio- and micro-eukaryotic communities in dam-induced river-reservoir systems
Although the Three Gorges Dam (TGD) is the world’s largest hydroelectric dam, little is known about the spatial–temporal patterns and community assembly mechanisms of meio- and micro-eukaryotes and its two sub...
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Open AccessPostnatal treatment and evolution patterns of giant fetal hepatic hemangioma: a case series of 29 patients
To explore the clinical characteristics, postnatal treatment and prognosis of giant fetal hepatic hemangioma (GFHH).
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Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Open Access\(Z_{cs}\) , \(Z_c\) and \(Z_b\) states under the complex scaling method
We investigate the \(Z_b\) Z b
