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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3β Signaling Pathway
To investigate the role of ginsenoside Rd (GRd) in acute myeloid leukemia (AML) cell differentiation.
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Article
Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications
Non-aromatic fluorescent and multi-responsive materials, exhibiting inherent fluorescence emission and controlled phase change, have garnered significant attention in recent years. However, the underlying inte...
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Article
[Rb3BaCl][In8Se14]: Compressed chalcopyrite-type selenide achieved by polycationic substitution strategy toward excellent nonlinear optical property
Incorporation of monovalent Ag+ or Li+ ions into the anionic groups MQ22− (M = Ga, In; Q = S, Se) within diamond-like structures holds great promise for the second-order nonlinear optical (NLO) crystals. However,...
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Article
Construction of LiCl/LiF/LiZn hybrid SEI interface achieving high-performance sulfide-based all-solid-state lithium metal batteries
Sulfide-based all-solid-state lithium metal batteries (ASSLMBs) have received extensive attention due to their high energy density and high safety, while the poor interface stability between sulfide electrolyt...
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Article
Open AccessMolecular orbital breaking in photo-mediated organosilicon Schiff base ferroelectric crystals
Ferroelectric materials, whose electrical polarization can be switched under external stimuli, have been widely used in sensors, data storage, and energy conversion. Molecular orbital breaking can result in sw...
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Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Article
Restoration of HMGCS2-mediated ketogenesis alleviates tacrolimus-induced hepatic lipid metabolism disorder
Tacrolimus, one of the macrolide calcineurin inhibitors, is the most frequently used immunosuppressant after transplantation. Long-term administration of tacrolimus leads to dyslipidemia and affects liver lipi...
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Article
Open AccessPD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression
Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molec...
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Article
Open AccessOsmosensor-mediated control of Ca2+ spiking in pollen germination
Higher plants survive terrestrial water deficiency and fluctuation by arresting cellular activities (dehydration) and resuscitating processes (rehydration). However, how plants monitor water availability durin...
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Article
Intermediate phase-assisted growth of CsPbBr3 for high performance of carbon-based perovskite solar cells
CsPbBr3 inorganic perovskites have been regarded as the promising materials in the field of photovoltaics because of the high tolerance against environment. The high energy barrier of phase transition from lead b...
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Article
Open AccessEnhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy
Extensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the luminal androgen receptor (LAR) subtype has attracted attentio...
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Article
In vivo manufacture and manipulation of CAR-T cells for better druggability
The current CAR-T cell therapy products have been hampered in their druggability due to the personalized preparation required, unclear pharmacokinetic characteristics, and unpredictable adverse reactions. Enab...
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Article
Open AccessGenome-wide analysis and expression profiling of the HD-ZIP gene family in kiwifruit
The homeodomain-leucine zipper (HD-Zip) gene family plays a pivotal role in plant development and stress responses. Nevertheless, a comprehensive characterization of the HD-Zip gene family in kiwifruit has bee...
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Article
Open AccessAcetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway
Pyroptosis of the renal tubular epithelial cells (RTECs) and interstitial inflammation are central pathological characteristics of acute kidney injury (AKI). Pyroptosis acts as a pro-inflammatory form of progr...
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Article
Author Correction: A second-generation M1-polarized CAR macrophage with antitumor efficacy
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Article
Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis
An electroencephalographic (EEG) signature of auditory hallucinations (AHs) is important for facilitating the diagnosis and treatment of AHs in schizophrenia. We recorded EEG from 25 schizophrenia patients wit...
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Article
Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy: a precise construction of structurally diverse azaspiro polycyclic scaffolds
A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic scaffolds. Structurally diverse azaspiro polycycles bearing multiple contiguous stereocenters are ob...
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Article
Open AccessMultimodal Fusion of Brain Imaging Data: Methods and Applications
Neuroimaging data typically include multiple modalities, such as structural or functional magnetic resonance imaging, diffusion tensor imaging, and positron emission tomography, which provide multiple views fo...
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Article
Predicting miRNA–Disease Associations by Combining Graph and Hypergraph Convolutional Network
miRNAs are important regulators for many crucial biological processes. Many recent studies have shown that miRNAs are closely related to various human diseases and can be potential biomarkers or therapeutic ta...
