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  1. Article

    Open Access

    PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression

    Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molec...

    Lin-Zhou Zhang, Jie-Gang Yang, Gai-Li Chen, Qi-Hui **e, Qiu-Yun Fu… in Nature Communications (2024)

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  2. No Access

    Article

    Endothelial cells induce degradation of ECM through enhanced secretion of MMP14 carried on extracellular vesicles in venous malformation

    Venous malformations (VMs), featuring localized dilated veins, are the most common developmental vascular anomalies. Aberrantly organized perivascular extracellular matrix (ECM) is one of the prominent patholo...

    Gao-Hong Chen, Jie-Gang Yang, Hou-Fu **a, Lin-Zhou Zhang… in Cell and Tissue Research (2022)

  3. Article

    Open Access

    Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

    Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aero...

    Hui-Min Li, Jie-Gang Yang, Zhuo-Jue Liu… in Journal of Experimental & Clinical Cancer … (2017)

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