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  1. No Access

    Article

    The Role of Histone H2B Acetylation Modification in Aluminum-Induced Cognitive Dysfunction

    Aluminum (Al) is a low toxic trace element that can accumulate in the nervous system and induce cognitive disorders characterized by reduced learning and memory ability. Neuroepigenetic effects are structural ...

    Jie Gao, Wei Liu, **g Pei, **g Li, Ni** Hao… in Biological Trace Element Research (2024)

  2. No Access

    Article

    Effects of miR-204-5p and Target Gene EphB2 on Cognitive Impairment Induced by Aluminum Exposure in Rats

    Aluminum is a common environmental neurotoxin. Aluminum ions can cross the blood–brain barrier and accumulate in different brain regions, damage brain tissue, and cause cognitive impairment, but the molecular ...

    Wei Liu, Jie Gao, Ni** Hao, **g Li, **g Pei… in Biological Trace Element Research (2024)

  3. No Access

    Article

    CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells

    Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the development of age-related macular degeneration (AMD), a pivotal facto...

    Rong Zhang, Lin Wang, Yang Li, Yan Liu, Kui Dong, Ya**g Pei, Junmei Zhao… in Human Cell (2024)

  4. No Access

    Article

    MAPK Signaling Pathway Plays Different Regulatory Roles in the Effects of Boric Acid on Proliferation, Apoptosis, and Immune Function of Splenic Lymphocytes in Rats

    Boron is one of the essential trace elements in animals. Although boron supplementation can enhance immune function and promote cell proliferation, high-dose boron supplementation can negatively affect immune ...

    Shuqin Chen, Haoran Fan, Yaqiong Pei, Kaihuan Zhang… in Biological Trace Element Research (2024)

  5. No Access

    Article

    Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardiac Cytoprotective Effects

    Resveratrol (Res) possesses various beneficial effects, including cardioprotective, anti-inflammatory, anti-aging, and antioxidant properties. However, the precise mechanism underlying these effects remains un...

    Pei Wang, Ying Yang, Jiabao Guo, Tingting Ma… in Biological Trace Element Research (2024)

  6. No Access

    Article

    Effect of Fluoride on the Expression of 8-Hydroxy-2′-Deoxyguanosine in the Blood, Kidney, Liver, and Brain of Rats

    Excessive exposure of fluoride not only leads to damage on bone, but also has an adverse effect on soft tissues. Oxidative DNA damage induced by fluoride is thought to be one of the toxic mechanisms of fluorid...

    Yongzheng Ma, **nyue Meng, Alphonse Sowanou, Jian Wang… in Biological Trace Element Research (2023)

  7. No Access

    Article

    Boric Acid Inhibits RANKL-Stimulated Osteoclastogenesis In Vitro and Attenuates LPS-Induced Bone Loss In Vivo

    Boron and boric acid (BA) can promote osteogenic differentiation and reduce bone resorption, which controls bone growth and maintenance of bone tissue. It has been reported that BA activates PERK-eIF2α signali...

    Bingbing Xu, Fanhe Dong, Pei Yang, Zihan Wang… in Biological Trace Element Research (2023)

  8. Article

    Open Access

    Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine

    Serine peptidase inhibitor Kazal type-1 (SPINK1), a trypsin kinase inhibitor, is known to be associated with inflammation and pathogenesis. The aim in this study was to demonstrate the clinicopathological role...

    Yi-Ting Chen, Tzu-Ting Tseng, Hung-Pei Tsai, Shih-Hsun Kuo, Ming-Yii Huang… in Human Cell (2022)

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  9. Article

    RETRACTED ARTICLE: Overexpression of CCN1 in esophageal squamous cell carcinoma attenuates cell proliferation through amyloid precursor protein without DR6 involvement

    Pei Wang, Zhiheng Chang, **g Meng, **a Cui, Jianyuan Chai, Tong Dang in Human Cell (2022)

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  10. No Access

    Article

    Association Between Osteoarthritis and Water Fluoride Among Tongyu Residents, China, 2019: a Case–Control of Population-Based Study

    Fluoride is an environmental chemical that has adverse effects on articular cartilage, probably increasing osteoarthritis (OA) risk. However, this association still needs more epidemiological evidence to clari...

    Alphonse Sowanou, **nyue Meng, Nan Zhong, Yongzheng Ma… in Biological Trace Element Research (2022)

  11. No Access

    Article

    Antioxidant Phytochemicals for the Prevention of Fluoride-Induced Oxidative Stress and Apoptosis: a Review

    Fluorosis is a major public health problem globally. The non-availability of specific treatment and the irreversible nature of dental and skeletal lesions poses a challenge in the management of fluorosis. Oxid...

    Linet M. Angwa, Yuting Jiang, Junrui Pei, Dianjun Sun in Biological Trace Element Research (2022)

  12. No Access

    Article

    Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation

    The vascular endothelium plays a key role in the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell Piezo1 mediates blood vessel formation, angiogenesis and regulation of blood pressure. ...

    Ying Yang, Danyang Wang, Chunxiao Zhang, Wenqing Yang, Chao Li, Zichen Gao… in Human Cell (2022)

  13. No Access

    Article

    Effect of Fluoride in Drinking Water on Fecal Microbial Community in Rats

    Intestinal nutrition has a close association with the onset and development of fluorosis. Intestinal microbes play a major role in intestinal nutrition. However, the effect of fluoride on intestinal microbes i...

    Nan Zhong, Yongzheng Ma, **nyue Meng, Alphonse Sowanou… in Biological Trace Element Research (2022)

  14. No Access

    Article

    Effects of Supranutritional Selenium Nanoparticles on Immune and Antioxidant Capacity in Sprague-Dawley Rats

    The present study was conducted to investigate the effects of supranutritional selenium nanoparticles (SeNPs) on immune and antioxidant capacity in rats. Forty male Sprague-Dawley (SD) rats were randomly divid...

    Yuyue **, Yudan He, Lujie Liu, Wen**g Tao, Geng Wang… in Biological Trace Element Research (2021)

  15. No Access

    Article

    Trelagliptin ameliorates oxygen–glucose deprivation/reperfusion (OGD/R)-induced mitochondrial dysfunction and metabolic disturbance of endothelial cells

    Acute myocardial infarction (AMI) is a severe cardiovascular disease with high mortality. It is reported to be closely related to the mitochondrial dysfunction and metabolic disturbance on endothelial cells un...

    Yatong Zhang, Chao Li, Yifang Pei, Li Zheng, Xuelin Sun, Zinan Zhao… in Human Cell (2021)

  16. No Access

    Article

    Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats

    Endemic fluorosis is a systemic chronic disease caused by excessive intake of fluoride. It is widely accepted that oxidative stress is closely related to fluorosis; however, molecular mechanism of oxidative st...

    Nan Zhong, Yingjie Yao, Yongzheng Ma, **nyue Meng… in Biological Trace Element Research (2021)

  17. No Access

    Article

    Effects of Replacing Inorganic with Respective Complexed Glycinate Minerals on Apparent Mineral Bioavailability and Deposition Rate in Tissues of Broiler Breeders

    The study was conducted to evaluate the effects of replacing inorganic trace minerals (ITMs) with respective low-dose complexed glycinate minerals (CGMs) on their bioavailability and retention during peak layi...

    Wan**g Sun, Geng Wang, Xun Pei, Lujie Liu… in Biological Trace Element Research (2020)

  18. No Access

    Article

    The Inverted U-Curve Association of Fluoride and Osteoclast Formation in Mice

    The effect of fluoride on osteoclasts is still controversial. In the past, researchers thought that the effects of fluoride on osteoclast and osteoblast formation occurred in a dose-dependent pattern. However,...

    Yingjie Yao, Yongzheng Ma, Nan Zhong, Junrui Pei in Biological Trace Element Research (2019)

  19. No Access

    Article

    Comparison of Inorganic and Organically Bound Trace Minerals on Tissue Mineral Deposition and Fecal Excretion in Broiler Breeders

    This study investigated the effects of replacement of inorganic trace minerals (ITMs) by organic trace minerals (OTMs) on tissue mineral retention and fecal excretion in “Zhen Ning” yellow feather broiler bree...

    Geng Wang, Lujie Liu, Zhongpei Wang, Xun Pei… in Biological Trace Element Research (2019)

  20. No Access

    Article

    Therapeutic Effect of Strontium Ranelate on Bone in Chemotherapy-Induced Osteopenic Rats via Increased Bone Volume and Reduced Bone Loss

    The purpose of this study was to determine whether treatment with strontium ranelate (SrR) can restore bone mass and strength at a skeletal site with established osteopenia in chemotherapy-induced rats. Forty-...

    Yi Pei, Ke Zheng, GuanNing Shang, YuMing Wang… in Biological Trace Element Research (2019)

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