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Article
Forecasting the Dst Index with Temporal Convolutional Network and Integrated Gradients
The Disturbance Storm Time (Dst) Index stands as a crucial geomagnetic metric, serving to quantify the intensity of geomagnetic disturbances. The accurate prediction of the Dst index plays a pivotal role in mi...
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Article
Open AccessPD-L1 expression in ovarian clear cell carcinoma using the 22C3 pharmDx assay
Ovarian clear cell carcinoma (OCCC), well known for its chemoresistance to platinum-based chemotherapy, exhibited a good response in clinical trials of anti–PD-1/PD-L1 inhibitors. By assessing PD-L1 expression...
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Article
Open AccessPhosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant cancer with poor overall survival. The application of sorafenib is a major breakthrough in the treatment of HCC. In our study, FOXQ1 was s...
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Article
Effect of Sintering Temperature on the Residual Stress of SrO-MgO-SiO2 Glass-Ceramic Sealant for Solid Oxide Fuel Cells
One of the critical issues in the efficient operation of the solid oxide fuel cell (SOFC) is the interface fracture caused by the release process of the residual stress inside the sealant in the thermal cycle....
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Article
Open AccessRBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma
Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary tract cancer. Our previous CCA mutation pattern study focused on genes in the post-transcription modification process, among which the altern...
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Article
Open AccessMicrobiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology. However, whether and h...
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Article
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
Cholangiocarcinoma (CCA), a primary hepatobiliary malignancy, is characterized by a poor prognosis and a lack of effective treatments. Therefore, the need to explore novel therapeutic approaches is urgent. Whi...
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Article
Experimental and Numerical Validation of an Effective Stress-Sensitive Permeability Model Under Hydromechanical Interactions
Water seepage in rocks, in geotechnical engineering such as the hydrofracturing of hard rocks, excavation of underground chambers, and prevention of mine water disasters, is a common problem. According to rock...
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Article
Comparison of I-ICME and M-ICME Fittings and In Situ Observation Parameters for Solar Cycles 23 and 24 and Their Influence on Geoeffectiveness
To understand the weaker geomagnetic activity in Solar Cycle 24, we present comparisons of interplanetary coronal mass ejections (ICMEs) fittings and in situ observation parameters in Solar Cycles 23 and 24. A...
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Article
Enhancing legal judgment summarization with integrated semantic and structural information
Legal Judgment Summarization (LJS) can highly summarize legal judgment documents, improving judicial work efficiency in case retrieval and other occasions. Legal judgment documents are usually lengthy; however...
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Article
Claudin18.2 expression in pulmonary mucinous adenocarcinoma
Pulmonary invasive mucinous adenocarcinoma (IMA) is a unique type of lung adenocarcinoma with a high recurrence rate and limited treatment strategies. The tight-junction-associated protein claudin18.2 is a new...
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Article
MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex
Spindle assembly checkpoint (SAC) plays an essential part in facilitating normal cell division. However, the clinicopathological and biological significance of mitotic arrest deficient 2 like 1 (MAD2/MAD2L1), ...
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Article
Integrating legal event and context information for Chinese similar case analysis
Similar case analysis (SCA) is an essential topic in legal artificial intelligence, serving as a reference for legal professionals. Most existing works treat SCA as a traditional text classification task and i...
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Article
Open AccessHypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation
Spindle and kinetochore-associated complex subunit 3 (SKA3) plays an important role in cell proliferation by regulating the separation of chromosomes and their division into daughter cells. Previous studies de...
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Article
Open AccessTheory analyses and applications of magnetic fluids in sealing
Magnetic fluids are the suspensions composed of magnetic nanoparticles, surfactants, and non-magnetic carrier liquids. Magnetic fluids are widely used in various fields, especially in sealing, because of their...
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Article
Open AccessOrigins of the open-circuit voltage in ternary organic solar cells and design rules for minimized voltage losses
The power conversion efficiency of ternary organic solar cells (TOSCs), consisting of one host binary blend and one guest component, remains limited by large voltage losses. The fundamental understanding of th...
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Article
In-flight calibration of the magnetometer on the Mars orbiter of Tianwen-1
Mars orbiter magnetometer (MOMAG) is one of seven science payloads onboard Tianwen-1’s orbiter. Unlike most of the satellites, Tianwen-1’s orbiter is not magnetically cleaned, and the boom where placed the mag...
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Article
Open AccessExploring the cellular and molecular differences between ovarian clear cell carcinoma and high-grade serous carcinoma using single-cell RNA sequencing and GEO gene expression signatures
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those...
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Article
Complete replacement of magnetic flux in a flux rope during a coronal mass ejection
Solar coronal mass ejections are the most energetic events in the Solar System. In their standard formation model, a magnetic flux rope builds up into a coronal mass ejection through magnetic reconnection that...
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Article
First results of the low energy ion spectrometer onboard a Chinese geosynchronous satellite
A Chinese geosynchronous satellite was launched on June 23, 2020. It carried a plasma detection package to monitor the space environment around the orbit. Here we report the inflight performance of a low energ...
