5,791 Result(s)

Article

Brain-Targeting Emodin Mitigates Ischemic Stroke via Inhibiting AQP4-Mediated Swelling and Neuroinflammation

Failure to achieve target-specific delivery to ischemic brain sites has hampered the clinical efficacy of newly developed therapies for ischemic stroke. Emodin, an active ingredient isolated from traditional C...

Yan-Yan Chen, Zhi-Cheng Gong, Mei-Mei Zhang… in Translational Stroke Research (2024)

Article

Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF

A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant neuronal excitability, synaptic impairment, and progressive cog...

Min-Nan Lu, Dan Wang, Chen-Jun Ye, Guo-Ji Yan, **g-Feng Song… in Molecular Neurobiology (2024)

Article

Research progress and development tendency on storage mechanism of multi-principal element alloys for hydrogen/tritium storage

Sustainable clean energy is gradually replacing traditional fossil energy sources in important industrial applications and is placing higher demands on the technologies of energy storage and transportation. Th...

Yi-Jie Chen, Jian-Wei Zhang, Can-Hui Xu, Mu-Hong Li, Shuang-Lin Hu… in Rare Metals (2024)

Article

Post-modification engineering of cerium metal-organic frameworks for efficient visible light-driven water oxidation

Metal-organic frameworks (MOFs) are highly desirable for promising photocatalytic water splitting, but their practical application is greatly limited due to their unstable chemical properties and insufficient ...

Lin-Zhu Zhang, Lu Chen, Gui-Yang Yan, Ruo-Wen Liang, Hong-Hui Ou in Rare Metals (2024)

Article

Asymmetric catalytic synthesis of chiral covalent organic framework composite (S)-DTP-COF@SiO₂ for HPLC enantioseparations by normal-phase and reversed-phase chromatographic modes

A novel CCOF core–shell composite material (S)-DTP-COF@SiO₂ was prepared via asymmetric catalytic and in situ growth strategy. The prepared (S)-DTP-COF@SiO₂ was utilized as separation medium for HPLC enantiosepar...

Hong-Mei Zhou, Cheng Liu, Yue Zhang, An-Xu Ma, Zong-Hong Luo… in Microchimica Acta (2024)

Article

Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2

Cerebral ischemic preconditioning (CIP) has been shown to improve brain ischemic tolerance against subsequent lethal ischemia. Reactive astrocytes play important roles in cerebral ischemia–reperfusion. Recent ...

**ao-Hua Liu, Ling-Yan Zhang, **-Yun Liu, **g-Ge Zhang… in Neurochemical Research (2024)

Article

Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis: A Multi-center, Double-Blinded and Randomized Controlled Trial

To assess the efficacy and safety of Bufei Jiedu (BFJD) ranules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis (MDR-PTB).

Shao-yan Zhang, Lei Qiu, Shun-xian Zhang… in Chinese Journal of Integrative Medicine (2024)

Article

Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction

Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...

**u-xiu Wang, Yi-ming Zhao, Qian-yun Zhang, **g-xuan Zhao… in Acta Pharmacologica Sinica (2024)

Article

Salvage haploidentical transplantation for graft failure after first haploidentical allogeneic stem cell transplantation: an updated experience

Graft failure is a fatal complication following allogeneic stem cell transplantation where a second transplantation is usually required for salvage. However, there are no recommended regimens for second transp...

Rui Ma, Dan-** Zhu, **ao-Hui Zhang, Lan-** Xu, Yu Wang… in Bone Marrow Transplantation (2024)

Article

Regioselective cation exchange reaction for photoelectrochemical water splitting

Mo-Yan Chen, Tai-Song Zhang, Zhi Yan, Jiang-Nan Lv, **ao-Ting Sun… in Rare Metals (2024)

Article

Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway

Parkin (PARK2) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin expression is downregulated in liver cancer tissues, which correlates wi...

Qi Su, **g-**g Wang, Jia-yan Ren, Qing Wu, Kun Chen… in Acta Pharmacologica Sinica (2024)

Article

Airways epithelial exposure to Streptococcus pneumoniae in the presence of the alarmin IL-33 induces a novel subset of pro-inflammatory ILC2s promoting a mixed inflammatory response

We have previously shown that asthma-like airways inflammation may be induced by topical exposure to respiratory tract pathogens such as S. pneumoniae (SP) in concert with epithelial alarmins such as IL-33. Detai...

**aonan Du, Yan Li, Yingjie Xu, Yiran Yang, Chenduo Li, Yan Chen… in Inflammation Research (2024)

Article

Abnormal phosphorylation / dephosphorylation and Ca²⁺ dysfunction in heart failure

Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca²⁺ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger sig...

Yan-Bing Liu, Qian Wang, Yu-Ling Song, **ao-Min Song, Yu-Chen Fan… in Heart Failure Reviews (2024)

Article

Spectrum optimization in cognitive satellite networks with graph coloring method

Cognitive satellite networks can enhance spectrum efficiency by enabling satellite networks to dynamically share idle spectrum with terrestrial networks. However, when taking into consideration the inter-cell ...

Li Wang, Kwok-Yan Lam, Jiangxin Zhang, Feng Li in Wireless Networks (2024)

Article

Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature

The continuing emergence of invasive fungal pathogens poses an increasing threat to public health. Here, through the China Hospital Invasive Fungal Surveillance Net programme, we identified two independent cas...

**g**g Huang, Pengjie Hu, Leixin Ye, Zhenghao Shen, … in Nature Microbiology (2024)

Article

ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway

Refractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is com...

Tianru Huyan, Lu Fan, Zhong-yuan Zheng, **g-hui Zhao… in Acta Pharmacologica Sinica (2024)