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54 Result(s)

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  1. No Access

    Article

    Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis

    Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that unde...

    Shu-qi Huang, Kai-xiang Cao, Cai-ling Wang, Pei-ling Chen… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy

    Hypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain HI injury. Pleckstr...

    **ao-lu Jiang, Zu-bin Zhang, Chen-xi Feng, Chen-jie Lin… in Acta Pharmacologica Sinica (2024)

  3. No Access

    Article

    Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model

    Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well controlled by current therapeutics. How epileptic seizure affects cognitive performance remains largely unclear. In thi...

    Lin Yang, Qi Zhang, Xue-qing Wu, **ao-yun Qiu, Fan Fei… in Acta Pharmacologica Sinica (2023)

  4. No Access

    Article

    Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection

    Although STAT3 has been reported as a negative regulator of type I interferon (IFN) signaling, the effects of pharmacologically inhibiting STAT3 on innate antiviral immunity are not well known. Capsaicin, appr...

    Mei-qi Zhang, **n Jia, Cui-qin Cheng, Yu-xi Wang, Yi-ying Li… in Acta Pharmacologica Sinica (2023)

  5. Article

    Open Access

    Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers

    Growth hormone secretagogue receptor 1a (GHS-R1a) is an important G protein-coupled receptor (GPCR) that regulates a variety of functions by binding to ghrelin. It has been shown that the dimerization of GHS-R...

    Ting-ting Tang, Ming-xia Bi, Mei-ning Diao, **ao-yi Zhang… in Acta Pharmacologica Sinica (2023)

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  6. No Access

    Article

    Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis

    Ferroptosis is a new form of regulated cell death characterized by excessive iron accumulation and uncontrollable lipid peroxidation. The role of ferroptosis in metabolic dysfunction-associated fatty liver dis...

    Jie Tong, **u-ting Lan, Zhen Zhang, Yi Liu, Di-yang Sun… in Acta Pharmacologica Sinica (2023)

  7. No Access

    Article

    Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R

    Although several KRasG12C inhibitors have displayed promising efficacy in clinical settings, acquired resistance developed rapidly and circumvented the activity of KRasG12C inhibitors. To explore the mechanism re...

    Wei-liang Qi, Hui-yu Li, Yi Wang, Lan Xu, Jie-ting Deng… in Acta Pharmacologica Sinica (2023)

  8. No Access

    Article

    Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown

    Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high vascularity and frequent metastasis. Tumor-associated abnormal vasculature was reported to accelerate TNBC metastasis. S...

    **-yu Mei, **g-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang… in Acta Pharmacologica Sinica (2022)

  9. No Access

    Article

    Rational application of gefitinib in NSCLC patients with sensitive EGFR mutations based on pharmacokinetics and metabolomics

    Gefitinib has been available in the market for 20 years, but its pharmacokinetic mechanism of response is little known. In this study, we examined the pharmacokinetic and metabolomic profiles in non-small cell...

    Wei Feng, ** Chen, Shao-xing Guan, Hong-lian Ruan, Yan Huang… in Acta Pharmacologica Sinica (2022)

  10. No Access

    Article

    Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis

    Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease characterized by destruction of lung parenchyma and deposition of extracellular matrix in interstitial and alveolar spaces. But known drugs f...

    Ying Dong, Bi-xi Tang, Qi Wang, Li-wei Zhou, Cong Li… in Acta Pharmacologica Sinica (2022)

  11. No Access

    Article

    Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model

    Furmonertinib (AST2818) is a novel third-generation irreversible EGFR TKI and recently has been approved in China for the treatment of non-small cell lung cancer (NSCLC) with EGFR-sensitizing and T790M resista...

    Hui-xi Zou, Yu-feng Zhang, Da-fang Zhong, Yong Jiang, Fei Liu… in Acta Pharmacologica Sinica (2022)

  12. No Access

    Article

    Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2

    Acute lung injury (ALI) is a sudden onset systemic inflammatory response. ALI causes severe morbidity and death and currently no effective pharmacological therapies exist. Natural products represent an excelle...

    Wu Luo, Li-bin Yang, Chen-chen Qian, Bao Ma… in Acta Pharmacologica Sinica (2022)

  13. No Access

    Article

    Repeated cocaine administration upregulates CB2 receptor expression in striatal medium-spiny neurons that express dopamine D1 receptors in mice

    Cannabinoid CB2 receptors (CB2R) are importantly involved in drug reward and addiction. However, the cellular mechanisms underlying CB2R action remain unclear. We have previously reported that cocaine self-admini...

    Hai-Ying Zhang, Lindsay De Biase, Ramesh Chandra, Hui Shen… in Acta Pharmacologica Sinica (2022)

  14. No Access

    Article

    AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner

    Targeting autophagy might be a promising anticancer strategy; however, the dual roles of autophagy in cancer development and malignancy remain unclear. NSCLC (non-small cell lung cancer) cells harbour high lev...

    Lin-lin Chang, Yue-kang Li, Chen-xi Zhao, Chen-ming Zeng… in Acta Pharmacologica Sinica (2022)

  15. Article

    Correction: 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis

    A Correction to this paper has been published: https://doi.org/10.1038/s41401-021-00670-z

    Ya-** Liao, Rui-yuan Pan, **ang-xi Kong, Yong Cheng, Lu Du… in Acta Pharmacologica Sinica (2022)

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  16. No Access

    Article

    P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

    Mantle cell lymphoma (MCL) is a lymphoproliferative disorder lacking reliable therapies. PI3K pathway contributes to the pathogenesis of MCL, serving as a potential target. However, idelalisib, an FDA-approved...

    **ao-ru Zhou, **ao Li, Li-** Liao, Jie Han, **g Huang… in Acta Pharmacologica Sinica (2022)

  17. No Access

    Article

    An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis

    Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovitis and the destruction of small joints. Emerging evidence shows that immunoglobulin D (IgD) stimulation induces T-cell...

    **ao-xi Hu, Ai-jun Zhang, Wen-wen Pan, Qian-ling **n… in Acta Pharmacologica Sinica (2022)

  18. No Access

    Article

    SAF-248, a novel PI3Kδ-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma

    PI3Kδ is expressed predominately in leukocytes and overexpressed in B-cell-related malignances. PI3Kδ has been validated as a promising target for cancer therapy, and specific PI3Kδ inhibitors were approved fo...

    ** Zhang, Yu-ting Duan, Yi Wang, **ng-dong Zhao, Yi-ming Sun… in Acta Pharmacologica Sinica (2022)

  19. No Access

    Article

    Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells

    Idiopathic pulmonary fibrosis (IPF) is an aging‐associated disease with a poor prognosis. Emerging evidence has revealed that targeting senescent cells may be a potential treatment for IPF. In this study, we a...

    Xuan Zhang, Ying Dong, Wan-chen Li, Bi-xi Tang, Jia Li… in Acta Pharmacologica Sinica (2021)

  20. No Access

    Article

    1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis

    NOD-like receptor (NLR) family pyrin domain-containing-3 (NLRP3) inflammasome is implicated in inflammation-associated diseases such as multiple sclerosis, Parkinson’s disease, and stroke. Targeting the NLRP3 ...

    Rui-yuan Pan, **ang-xi Kong, Yong Cheng, Lu Du… in Acta Pharmacologica Sinica (2021)

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