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  1. No Access

    Article

    Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection

    Although STAT3 has been reported as a negative regulator of type I interferon (IFN) signaling, the effects of pharmacologically inhibiting STAT3 on innate antiviral immunity are not well known. Capsaicin, appr...

    Mei-qi Zhang, **n Jia, Cui-qin Cheng, Yu-xi Wang, Yi-ying Li… in Acta Pharmacologica Sinica (2023)

  2. No Access

    Article

    Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases

    Recent evidence shows that targeting NLRP3 inflammasome activation is an important means to treat inflammasome-driven diseases. Scoparone, a natural compound isolated from the Chinese herb Artemisia capillaris Th...

    Wan-di Feng, Yao Wang, Tong Luo, **n Jia, Cui-qin Cheng… in Acta Pharmacologica Sinica (2023)

  3. Article

    Open Access

    Role of OAS gene family in COVID-19 induced heart failure

    COVID-19, the current global pandemic caused by SARS-CoV-2 infection, can damage the heart and lead to heart failure (HF) and even cardiac death. The 2',5'-oligoadenylate synthetase (OAS) gene family encode in...

    Li-Juan Gao, Zhong-Mei He, Yi-Ying Li, Rui-Rui Yang… in Journal of Translational Medicine (2023)

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