![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessA photocatalytic redox cycle over a polyimide catalyst drives efficient solar-to-H2O2 conversion
Circumventing the conventional two-electron oxygen reduction pathway remains a great problem in enhancing the efficiency of H2O2 photosynthesis. A promising approach to achieve outstanding photocatalytic activity...
-
Article
Open AccessIon pair sites for efficient electrochemical extraction of uranium in real nuclear wastewater
Electrochemical uranium extraction from nuclear wastewater represents an emerging strategy for recycling uranium resources. However, in nuclear fuel production which generates the majority of uranium-containin...
-
Article
Open AccessAuthor Correction: Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer
-
Article
Open AccessSpatially organized cellular communities form the develo** human heart
The heart, which is the first organ to develop, is highly dependent on its form to function1,2. However, how diverse cardiac cell types spatially coordinate to create the complex morphological structures that are...
-
Article
Open AccessSynthesis of core@shell catalysts guided by Tammann temperature
Designing high-performance thermal catalysts with stable catalytic sites is an important challenge. Conventional wisdom holds that strong metal-support interactions can benefit the catalyst performance, but th...
-
Article
Open AccessMCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation
Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed in activated B cells, it is not clear how MCT1-governed monocarboxylate...
-
Article
Open AccessFirst close insight into global daily gapless 1 km PM2.5 pollution, variability, and health impact
Here we retrieve global daily 1 km gapless PM2.5 concentrations via machine learning and big data, revealing its spatiotemporal variability at an exceptionally detailed level everywhere every day from 2017 to 202...
-
Article
Open AccessSingle cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we perform single-cell RNA-seque...
-
Article
Open AccessUncertainty-inspired open set learning for retinal anomaly identification
Failure to recognize samples from the classes unseen during training is a major limitation of artificial intelligence in the real-world implementation for recognition and classification of retinal anomalies. W...
-
Article
Open AccessNeuro-inspired optical sensor array for high-accuracy static image recognition and dynamic trace extraction
Neuro-inspired vision systems hold great promise to address the growing demands of mass data processing for edge computing, a distributed framework that brings computation and data storage closer to the source...
-
Article
Open AccessSingle-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor ti...
-
Article
Open AccessNon-volatile optoelectronic memory based on a photosensitive dielectric
Recently, the optoelectronic memory is capturing growing attention due to its integrated function of sense and memory as well as multilevel storage ability. Although tens of states have been reported in litera...
-
Article
Open AccessPhosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intr...
-
Article
Open AccessGenome-wide association studies identify OsWRKY53 as a key regulator of salt tolerance in rice
Salinity stress progressively reduces plant growth and productivity, while plant has developed complex signaling pathways to confront salt stress. However, only a few genetic variants have been identified to m...
-
Article
Open AccesscircDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations
Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing b...
-
Article
Open AccessExploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch
Autologous skin flap transplantation is a common method for repairing complex soft tissue defects caused by cancer, trauma, and congenital malformations. Limited blood supply range and post-transplantation isc...
-
Article
Open AccessEngineering inducible biomolecular assemblies for genome imaging and manipulation in living cells
Genome architecture and organization play critical roles in cell life. However, it remains largely unknown how genomic loci are dynamically coordinated to regulate gene expression and determine cell fate at th...
-
Article
Open AccessSARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated wi...
-
Article
Open AccessDiscovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells
SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum anti...
-
Article
Open AccessAccelerated pyro-catalytic hydrogen production enabled by plasmonic local heating of Au on pyroelectric BaTiO3 nanoparticles
The greatest challenge that limits the application of pyro-catalytic materials is the lack of highly frequent thermal cycling due to the enormous heat capacity of ambient environment, resulting in low pyro-cat...