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Article
Exploring the binding mechanism of a small molecular Hsp70-Bim PPI inhibitor through molecular dynamic simulation
The interface of Hsp70-Bim protein–protein interaction (PPI) has been identified as a specific target for Chronic Myeloid Leukemia (CML) therapy and the specific inhibitors were developed to exhibit in vivo an...
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Article
Open AccessEctopic BH3-Only Protein Bim Associates with Hsp70 to Regulate Yeast Mitophagy
Mitophagy, a form of selective autophagy, plays an essential role to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Acting mainly as one of the B-cell lymphoma 2 (...
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Article
Open AccessPhosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intr...
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Article
High dielectric constant polyimide for high-temperature film capacitor by tuning macroconjugated molecule
Polymer film capacitors do not meet the increasing demand of high-temperature (> 125 °C) applications with the rapid development of new energy. In particular, few polymer dielectrics can operate at high temper...
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Article
Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: a potential role for the chemokine CXCL16
ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways. We investigated the time course of ILC2 accumulation in different tissues in muri...
