11 Result(s)
within
**-Yee Law
Cell Biology
-
Article
Open AccessWRN loss accelerates abnormal adipocyte metabolism in Werner syndrome
Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vi...
-
Article
Prognostic impact of the adverse molecular-genetic profile on long-term outcomes following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
The impact of adverse risk genetic profiles on outcomes in acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HCT) has not been fully elucidated. Accordingly, w...
-
Article
Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner
Opioids, like morphine and naloxone, regulate the proliferation and neuronal differentiation of neural stem cells (NSCs) in a receptor-independent and ten-eleven translocation methylcytosine dioxygenase (TET1)...
-
Article
Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,8...
-
Article
Effects of addictive drugs on adult neural stem/progenitor cells
Neural stem/progenitor cells (NSPCs) undergo a series of developmental processes before giving rise to newborn neurons, astrocytes and oligodendrocytes in adult neurogenesis. During the past decade, the role o...
-
Article
MicroRNAs in Opioid Pharmacology
MicroRNAs (miRNA), a class of ~22-nucleotide RNA molecules, are important gene regulators that bind to the target sites of mRNAs to inhibit the gene expressions either through translational inhibition or mRNA ...
-
Article
Open AccessPalmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling
A cholesterol-palmitoyl interaction has been reported to occur in the dimeric interface of the β2-adrenergic receptor crystal structure. We sought to investigate whether a similar phenomenon could be observed wit...
-
Article
Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F
Classical opioids have been historically used for the treatment of pain and are among the most widely used drugs for both acute severe pain and long-term pain. Morphine and endogenous mu-opioid peptides exert the...
-
Article
Neurite Outgrowth is Dependent on the Association of c-Src and Lipid Rafts
Regulation of neurite outgrowth is an important aspect not only for proper development of the nervous system but also for tissue regeneration after nerve injury and the treatment of neuropathological condition...
-
Article
Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1)
The pharmacological effects of morphine and morphine-like drugs are mediated primarily through the µ opioid receptor. Here we show that differential use of an in-frame translational start codon in the 5′-untra...
-
Article
Nuclear Factor κB Signaling in Opioid Functions and Receptor Gene Expression
Opiates are the most powerful of all known analgesics. The prototype opiate morphine has been used as a painkiller for several thousand years. Chronic usage of opiates not only causes drug tolerance, dependenc...
