10,683 Result(s)
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**-Wen Chen
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Article
Cimifugin Mechanism of Action from Saposhnikovia divaricata in the Treatment of Atopic Dermatitis
The present study aimed to explore the mechanism of action of cimifugin, the primary active ingredient in Saposhnikovia divaricata (Turcz.) Schischk., Apiaceae, in treating atopic dermatitis. BALB/c mice were gro...
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Atypical phenotypes and novel OCRL variations in southern Chinese patients with Lowe syndrome
Lowe syndrome is characterized by the presence of congenital cataracts, psychomotor retardation, and dysfunctional proximal renal tubules. This study presents a case of an atypical phenotype, investigates the ...
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Assessing and optimizing the bioactivities of diverse enzyme-derived protein hydrolysates from Porphyra yezoensis: unlocking the health potential
The interest in algae-derived bioactive compounds has grown due to their potential therapeutic efficacy against a range of diseases. These compounds, derived from proteins, exhibit diverse functions and profou...
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In vitro evaluation of antioxidant potential of polysaccharides and oligosaccharides extracted from three different seaweeds
Bioactive polysaccharides and oligosaccharides were successfully extracted from three distinct seaweeds: Sargassum sp., Graciallaria sp., and Ulva sp. utilizing various extraction techniques. The obtained polysac...
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Article
Open AccessN6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
The potential involvement of circular RNAs (circRNAs) and N6-methyladenosine (m6A) modification in the progression of Wilms tumor (WT) has not been fully elucidated. This study investigates the regulatory mechani...
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Analysis of the implementation of the certification of second-tier quality control in Taiwan food businesses and common non-conformities
The Taiwan Food and Drug Administration has implemented a three-tier quality control system to enhance food safety. This system includes self-management of food businesses, external certification, and governme...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Redundancy and hierarchical cluster analyses for characterizing geomorphic features contributing to the formation of landslide dams
Landslides frequently produce dams that can cause widespread destruction when breached. Several factors influence the formation of landslide dams. This study used redundant analysis and hierarchical cluster an...
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Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster proteins as a unique copper-dependent form of regulated cell dea...
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Article
Enantioselective alkene hydroalkylation overcoming heteroatom constraints via cobalt catalysis
Alkene hydroalkylation enables efficient and selective formation of C(sp3)–C(sp3) bonds with unique advantages, such as exceptional chemoselectivity and remarkable tolerance of functional groups. However, elimina...
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Article
Open AccessAutomatic wild bird repellent system that is based on deep-learning-based wild bird detection and integrated with a laser rotation mechanism
Wild bird repulsion is critical in agriculture because it helps avoid agricultural food losses and mitigates the risk of avian influenza. Wild birds transmit avian influenza in poultry farms and thus cause lar...
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Application of Phosphorylated Tau for Predicting Outcomes Among Sudden Cardiac Arrest Survivors
Phosphorylated Tau (p-Tau), an early biomarker of neuronal damage, has emerged as a promising candidate for predicting neurological outcomes in cardiac arrest (CA) survivors. Despite its potential, the correla...
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Article
ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the olfactory bulb (OB) ...
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Open AccessEfficacy of tibial cortex transverse transport in treating diabetic foot ulcer and its effect on serum omentin-1 and irisin levels
Diabetic foot ulcer (DFU) is a common and debilitating complication of diabetes that is associated with an increased risk of lower-limb amputation and a reduced life expectancy. Tibial cortex transverse transp...
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Article
Two Monte Carlo-based simulators for imaging-system modeling and projection simulation of flat-panel X-ray source
The advantages of a flat-panel X-ray source (FPXS) make it a promising candidate for imaging applications. Accurate imaging-system modeling and projection simulation are critical for analyzing imaging performa...
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Open AccessPerformance of Microsoft Azure Kinect DK as a tool for estimating human body segment lengths
The Microsoft Kinect depth sensor, with its built-in software that automatically captures joint coordinates without markers, could be a potential tool for ergonomic studies. This study investigates the perform...
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Age-adjusted Charlson Comorbidity Index as an effective tool for the choice between simultaneous or staged bilateral total knee arthroplasty
The choice between simultaneous and staged bilateral total knee arthroplasty (BTKA) remains controversial. Age-adjusted Charlson Comorbidity Index(CCI) is a promising tool for risk-stratification. We aimed to ...
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Open AccessReactive oxygen species/glutathione dual sensitive nanoparticles with encapsulation of miR155 and curcumin for synergized cancer immunotherapy
Considerable attention has been directed towards exploring the potential efficacy of miR-155 in the realm of cancer immunotherapy. Elevated levels of miR-155 in dendritic cells (DCs) have been shown to enhance...
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Article
Open AccessRefining silicon nitride waveguide quality through femtosecond laser annealing
We present a method for modification of silicon nitride (Si3N4) waveguide resonators using femtosecond laser annealing. The quality (Q) factor of the waveguide resonators can be improved by approximately 1.3 time...
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Article
Open AccessFERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells
Glioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment outcomes. Cancer stem cells (CSCs) have emerged as key contributors to tumor relapse an...
