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  1. Article

    Open Access

    Nusinersen effectiveness and safety in pediatric patients with 5q-spinal muscular atrophy: a multi-center disease registry in China

    To evaluate the effectiveness and safety of nusinersen for the treatment of 5q-spinal muscular atrophy (SMA) among Chinese pediatric patients.

    **aoli Yao, **g Peng, Rong Luo, **uxia Wang, **nguo Lu, Liwen Wu… in Journal of Neurology (2024)

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  2. Article

    Open Access

    Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers

    The majority of smokers relapse even after successfully quitting because of the craving to smoking after unexpectedly re-exposed to smoking-related cues. This conditioned craving is mediated by reward memories...

    **ao Lin, Jiahui Deng, Kai Yuan, Qiandong Wang, Lin Liu… in Translational Psychiatry (2021)

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  3. No Access

    Article

    MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer’s disease by targeting heat shock protein B8

    Alzheimer’s disease (AD) is the most prevalent and age-related dementia accompanied by neurodegenerative disorder, memory loss, and abnormal behaviors. Recent studies have shown an increasing interest in study...

    Jiao Yuan, Yanpeng Wu, Lu Li, Chuanqin Liu in Journal of Neural Transmission (2020)

  4. No Access

    Article

    A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling

    Presenilin-1 (PSEN1) is the catalytic subunit of the γ-secretase complex, and pathogenic mutations in the PSEN1 gene account for the majority cases of familial AD (FAD). FAD-associated mutant PSEN1 proteins have ...

    Shuting Zhang, Fang Cai, Yili Wu, Tahereh Bozorgmehr, Zhe Wang… in Molecular Psychiatry (2020)

  5. Article

    Open Access

    Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau

    While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson’s disease (PD), little is known about the mechanism through which huma...

    Ting-Han Wu, Yu-Ning Lu, Chia-Lung Chuang, Chia-Lin Wu… in Acta Neuropathologica (2013)

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  6. No Access

    Article

    A 14 bp indel variation in the NCX1 gene modulates the age at onset in late-onset Alzheimer’s disease

    Calcium homeostasis is critical to amyloid beta precursor protein (APP) processing. Na+/Ca2+ exchanger (NCX) proteins play an important role in maintaining intracellular Na+ and Ca2+ homeostasis in the brain unde...

    **u-Hua Bi, Cui-Min Lu, Qian Liu, Zhen-**n Zhang… in Journal of Neural Transmission (2012)

  7. No Access

    Article

    Association analysis of CβS 844ins68 and MTHFD1 G1958A polymorphisms with Alzheimer’s disease in Chinese

    Folate deficiency and elevated plasma homocysteine play important roles in pathogenesis of Alzheimer’s disease (AD). The aim of this study was to test the association of folate metabolism-related genes, cystat...

    **u-Hua Bi, Hua-Lu Zhao, Zhen-**n Zhang, Qian Liu… in Journal of Neural Transmission (2010)

  8. No Access

    Chapter and Conference Paper

    Genetic and DAT imaging studies of familial parkinsonism in a Taiwanese cohort

    We here summarize the results of genetic investigations on a series of 82 parkinsonian patients from 60 families in Taiwan. We found 13 parkin patients in 7 families (12%), 2 PINK1 sibs from 1 family, and 1 LRRK2

    C. -S. Lu, Y. -H. Wu Chou, Y. -H. Weng… in Parkinson’s Disease and Related Disorders (2006)