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Article
Mendelian Randomization Identifies Genetically Supported Drug Targets for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Currently, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have no effective treatments. Drug repurposing offers a rapid method to meet therapeutic need for ALS and FTD. To identify thera...
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Article
Tame parahoric nonabelian Hodge correspondence in positive characteristic over algebraic curves
Let G be a reductive group, and let X be an algebraic curve over an algebraically closed field k with positive characteristic. We prove a version of nonabelian Hodge correspondence for tame G-local systems over X
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Article
Open AccessUnravelling the dynamics of technology integration in mathematics education: A structural equation modelling analysis of TPACK components
This quantitative study examined the dynamics of the Technological Pedagogical Content Knowledge (TPACK) framework within mathematics education, centring on the role of Contextual Knowledge (XK). The research,...
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Article
Open AccessPredictive value of preoperative CT enhancement rate and CT perfusion parameters in colorectal cancer
Angiogenesis is a critical step in colorectal cancer growth, progression and metastasization. CT are routine imaging examinations for preoperative clinical evaluation in colorectal cancer patients. This study ...
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Article
Open AccessA systematic review of TPACK research in primary mathematics education
This study is a systematic review of Technological Pedagogical and Content Knowledge (TPACK) studies concerning primary mathematics education published between 2005 and 2022. The aim of the systematic review w...
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Article
Differential selection of yield and quality traits has shaped genomic signatures of cowpea domestication and improvement
Cowpeas (tropical legumes) are important in ensuring food and nutritional security in develo** countries, especially in sub-Saharan Africa. Herein, we report two high-quality genome assemblies of grain and v...
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Article
Open AccessAsiaticoside alleviates lipopolysaccharide-induced acute lung injury by blocking Sema4D/CD72 and inhibiting mitochondrial dysfunction in RAW264.7 cell and mice
Acute lung injury (ALI) is a common disease with complex pathogenesis. However, the treatment is mainly symptomatic with limited clinical options. Asiaticoside (AS), a Chinese herbal extract, has protective ef...
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Article
Structural reconstruction and thermophysical properties of alumina agglomerate based on QSGS calculation
The presence of alumina agglomerates seriously affects the current efficiency of the aluminum electrolysis process. The microstructure of agglomerate is difficult to obtain while it is crucial for exploring th...
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Article
Open AccessQuantitative association between lead exposure and amyotrophic lateral sclerosis: a Bayesian network-based predictive study
Environmental lead (Pb) exposure have been suggested as a causative factor for amyotrophic lateral sclerosis (ALS). However, the role of Pb content of human body in ALS outcomes has not been quantified clearly...
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Article
Serum Cystatin C is a potential biomarker for predicting amyotrophic lateral sclerosis survival
Currently, it is unclear whether serum Cystatin C can be used to evaluate the prognosis of ALS. We aim to study the relationship between serum Cystatin C and survival in ALS.
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Article
Open AccessDCE-MRI-based radiomics in predicting angiopoietin-2 expression in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third leading cause of cancer death worldwide. Studies have shown that increased angiopoietin-2 (Ang-2) expression relative to Ang-1 expr...
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Article
Differentiable visual computing for inverse problems and machine learning
Modern 3D computer graphics technologies are able to reproduce the dynamics and appearance of real-world environments and phenomena, building on theoretical models in applied mathematics, statistics and physic...
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Article
Improvement of Photosynthetic Performance by Acetic Acid to Enhance Drought Tolerance in Common Bean (Phaseolus vulgaris)
Common bean (Phaseolus vulgaris) is an essential crop. Unfortunately, it is hypersensitive to abiotic stresses, especially drought. Recently, chemical applications have proved to be a prominent approach for enhan...
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Article
Evaluating the causal association between microRNAs and amyotrophic lateral sclerosis
Currently, miRNAs are involved in the development of amyotrophic lateral sclerosis (ALS), and identifying circulating miRNAs that are causally associated with ALS risk as biomarkers is imperative.
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Article
Open AccessGenetically proxied antidiabetic drugs targets and stroke risk
Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on str...
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Article
Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia‒reperfusion injury by inducing ferroptosis propagation
Ferroptosis is a predominant contributor to renal ischemia reperfusion injury (IRI) after kidney transplant, evoking delayed graft function and poorer long-term outcomes. The wide propagation of ferroptosis am...
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Article
Open AccessVitamin D is inversely associated with Monocyte to HDL-C ratio among medical staff in Chengdu, China
The primary objective of this study was to explore the association of vitamin D with the monocyte to HDL-C ratio (MHR) among medical staff in Chengdu, China.
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Article
Effects of induction furnace conditions on lining refractory via multi-physics field simulation
Coreless induction furnace is one of the most widely used equipment in the steelmaking sector, while the lining refractory are the key factors in determining the lifetime of the induction furnace. The multi-ph...
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Article
Open AccessNeuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson’s disease via inhibiting oxidative stress and ferroptosis
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease accompanied by the death of dopaminergic neurons and brain nigrostriatal mitochondrial damage in the elder...
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Article
Open AccessHypertension, antihypertensive drugs, and age at onset of Huntington’s disease
Associations between blood pressure (BP) with age at onset of Huntington’s disease (HD) have reported inconsistent findings. We used Mendelian randomization (MR) to assess effects of BP and lowering systolic B...
