366 Result(s)
within
English
Biomedicine
Biomedicine, general
Oncology
** Chung
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Article
Intestinal polyps in American negroes and Nigerian africans
Forty Africans from Nigeria and 89 American negroes with colorectal polyps were analysed by age, sex and type of polyp. The Nigerians were much the younger group (mostly under 20 years of age, whereas most of ...
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Article
Recombinant α2 interferon is superior to doxorubicin for inoperable hepatocellular carcinoma: a prospective randomised trial
In a prospective trial of 75 Chinese patients with histologically proven inoperable hepatocellular carcinoma (HCC), 25 patients were randomised to receive doxorubicin 60-75 mg m-2 intravenously once every 3 we...
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Article
Fibroblasts are critical determinants in prostatic cancer growth and dissemination
Fibroblasts are important contributors to both benign and malignant growth of prostate epithelial cells in vivo. In the human prostate cancer model that we have established, we can grow human LNCaP tumors reprodu...
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Haemostatic changes and thromboembolic risk during tamoxifen therapy in normal women
Tamoxifen has been implicated as a risk factor for venous thrombosis in advanced breast cancer although the evidence for increased arterial or venous thrombosis with tamoxifen in early breast cancer is less cl...
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Article
Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus
The expression of the regulatory (RI and RII) and catalytic (C) subunits of cAMP-dependent protein kinase was found to depend on the growth-state in oestrogen-dependent DMBA-induced mammary adenocarcinomas as ...
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In vivo andin vitro approaches to study metastasis in human prostatic cancer
Prostate cancer is the most common malignancy in American males and is second only to lung cancer as a cause of death in the United States. Clinically, radical prostatectomy offers a patient with locally conta...
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Article
Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa
Photoaffinity labelling (PAL) with [32P]8-azido-cAMP and polyacrylamide gel electrophoresis (PAGE) has been used to identify three specific cAMP-binding proteins (cAMP-BPs) within cytosols derived from the cen...
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Article
Establishment of a new human extrahepatic bile duct carcinoma cell line (OCUCh-LM1) and experimental liver metastatic model
A new human extrahepatic bile duct carcinoma cell line, designated OCUCh-LM1, was established from a liver metastatic lesion in a 61-year-old male. OCUCh-LM1 cells proliferated in a monolayered sheet with a po...
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Article
Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen
The clinical importance of microvessel quantitation as a prognostic indicator in invasive breast cancer was examined. This study included 155 patients with invasive breast cancer, with a median follow-up of 82...
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Article
Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma
Tumour growth depends on neovascularisation and tumour cell proliferation. Factor VIII-related antigen (F-VIII RA) localises to vascular endothelium. Expression of proliferating cell nuclear antigen (PCNA) is ...
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Article
Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis
Determination of the differences between cell lines which are derived from a primary tumour and a disseminated metastatic lesion from the same patient may aid in elucidating the factors associated with dissemi...
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Article
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
We established a peritoneal-metastatic model for scirrhous gastric carcinoma. Peritoneal metastasis had developed after intraperitoneal inoculation of OCUM-2MD3 cells in nude mice. This cell line was derived f...
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Article
Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma
It is known that angiogenesis plays an important role in the growth and metastasis of solid tumours. Several angiogenic factors have been identified and platelet-derived endothelial cell growth factor (PD-ECGF...
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Article
Clinical significance of serum CYFRA 21-1 in gastric cancer
We studied the clinical significance of the soluble cytokeratin 19 fragment detected with monoclonal antibody CYFRA 21-1 in the sera of patients with histologically proven gastric cancer. Sera of 110 patients ...
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Article
Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts
Scirrhous gastric cancer cells proliferate rapidly with fibrosis, when the cancer cells invade into the submucosa of the stomach. To investigate the mechanisms responsible for the rapid proliferation, the grow...
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Article
Role of alpha 2 beta 1- and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma
We established a highly peritoneal-seeding cell line, OCUM-2MD3, from a poorly peritoneal-seeding cell line, OCUM-2M, of human scirrhous gastric carcinoma. The intraperitoneal inoculation of OCUM-2MD3 cells pr...
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Article
Sequential activation and production of matrix metalloproteinase-2 during breast cancer progression
The proteolytic processes are thought to be the critical point in tumor invasion and metastasis, mainly by matrix metalloproteinases (MMPs) and serine proteases. We measured the activity of MMP-2 from 28 norma...
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Article
Genetic changes associated with the acquisition of androgen-independent growth, tumorigenicity and metastatic potential in a prostate cancer model
Genetic changes underlying the progression of human prostate cancer are incompletely understood. Recently, an experimental model system that resembles human prostate cancer progression was developed based on t...
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Article
Identification and characterization of motility stimulating factor secreted from pancreatic cancer cells: role in tumor invasion and metastasis
Cell motility is an important factor in the process of invasion and metastasis of tumor. In this study, the relationship between cell motility and experimental metastatic potential was examined using two human...
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Article
Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma
Previous studies have shown that tumour-suppressor genes play an important role in the progression of solid tumours. Recently, the p21WAF1/CIP1 tumour-suppressor protein has been reported to work as a critical...
