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Article
Open AccessEnhanced polarization switching characteristics of HfO2 ultrathin films via acceptor-donor co-do**
In the realm of ferroelectric memories, HfO2-based ferroelectrics stand out because of their exceptional CMOS compatibility and scalability. Nevertheless, their switchable polarization and switching speed are not...
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Article
Open AccessCarbapenem-resistant Escherichia coli exhibit diverse spatiotemporal epidemiological characteristics across the globe
Carbapenem-resistant Escherichia coli (CREC) poses a severe global public health risk. This study reveals the worldwide geographic spreading patterns and spatiotemporal distribution characteristics of resistance ...
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Article
Open AccessRapidly adaptable automated interpretation of point-of-care COVID-19 diagnostics
Point-of-care diagnostic devices, such as lateral-flow assays, are becoming widely used by the public. However, efforts to ensure correct assay operation and result interpretation rely on hardware that cannot ...
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Article
Optimization of 5′UTR to evade SARS-CoV-2 Nonstructural protein 1-directed inhibition of protein synthesis in cells
Maximizing the expression level of therapeutic proteins in cells is the general goal for DNA/mRNA therapies. It is particularly challenging to achieve efficient protein expression in the cellular contexts wit...
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Article
Correction: Identification of extracellular vesicles from J strain and wild isolate of Mycoplasma hyopneumoniae
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Article
Open AccessIdentification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus
Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and c...
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Article
Open AccessGender differences in the intention to withhold life-sustaining treatments involving severe dementia for self and on behalf of parent or spouse
Few studies have explored gender differences in the attitudes toward advanced care planning and the intention to withhold life-sustaining treatments (LSTs) involving severe dementia in Asian countries. We exam...
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Open AccessCorrection: Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index
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Open AccessSystemic Therapy for Gastrointestinal Stromal Tumor: Current Standards and Emerging Challenges
Gastrointestinal stromal tumor (GIST), though rare, is the most common mesenchymal tumors of the gastrointestinal tract. KIT or PDGFRα mutation plays as an oncogenic driver in the majority of GISTs. Surgical rese...
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Article
Open AccessGlobal antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index
Antimicrobial resistance (AMR) is one of the top ten global public health challenges. However, given the lack of a comprehensive assessment of worldwide AMR status, our objective is to develop a One Health-bas...
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Article
Open AccessSerological and molecular characteristics of pathogenic Leptospira in rodent populations in Fujian Province, China, 2018–2020
Leptospirosis is a significant emerging infectious disease worldwide. Rodents are considered to be the most critical hosts of Leptospira spp. Fujian Province is a region highly endemic for leptospirosis in China....
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Article
Open AccessTwisted oxide lateral homostructures with conjunction tunability
Epitaxial growth is of significant importance over the past decades, given it has been the key process of modern technology for delivering high-quality thin films. For conventional heteroepitaxy, the selection...
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Article
Open AccessBarium hexaferrite/muscovite heteroepitaxy with mechanically robust perpendicular magnetic anisotropy
Recent advances in the design and development of magnetic storage devices have led to an enormous interest in materials with perpendicular magnetic anisotropy (PMA) property. The past decade has witnessed a hu...
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Article
Open AccessReal-world effectiveness of second-line Afatinib versus chemotherapy for the treatment of advanced lung squamous cell carcinoma in immunotherapy-naïve patients
Limited treatment options exist for relapsed advanced lung squamous cell carcinoma (SCC), leading to poor outcomes compared with adenocarcinoma. This study aimed to investigate the efficacy of second-line afat...
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Article
Open AccessOne colorful resolution to the neutrino mass generation, three lepton flavor universality anomalies, and the Cabibbo angle anomaly
We propose a simple model to simultaneously explain four observed flavor anomalies while generating the neutrino mass at the one-loop level. Specifically, we address the measured anomalous magnetic dipole mome...
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Open AccessFeasibility and effectiveness of afatinib for poor performance status patients with EGFR-mutation-positive non-small-cell lung cancer: a retrospective cohort study
Afatinib is one of the standard treatments for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). However, data on the use of afatinib in patients with poor performa...
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Article
Open AccessMedical students’ affective reactions to workplace experiences: qualitative investigation in a Chinese cultural context
Compassion fatigue, unprofessional behavior, and burnout are prompting educators to examine medical students’ affective reactions to workplace experiences. Attributes of both students and learning environments...
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Article
Open AccessThe association between immune-related adverse events and survival outcomes in Asian patients with advanced melanoma receiving anti-PD-1 antibodies
The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, ...
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Article
Open AccessComparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery
Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine a...
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Article
Open AccessSerum IP-10 and IL-17 from Kawasaki disease patients induce calcification-related genes and proteins in human coronary artery smooth muscle cells in vitro
Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD pat...
