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  1. No Access

    Chapter and Conference Paper

    Preliminary Results of Treatment with Itraconazole in Patients with Systemic Fungal Infections

    Patients with acute leukemias undergo a high risk of lethal systemic fungal infections during prolonged periods of granulocytopenia. While amphotericin B is still the most effective antimycotic drug, its use i...

    H.-H. Wolf, R. E. Scharf, M. Arning, W. Schneider in Acute Leukemias II (1990)

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    Chapter and Conference Paper

    Influence of Infusion Time on the Acute Toxicity of Amphotericin B: Results of a Randomized Double-Blind Study

    Despite the development of several new antifungal drugs, intravenous amphotericin B (amB) is still considered the drug of choice for the treatment of severe systemic fungal infections in immunocompromised pati...

    M. Arning, B. Dresen, C. Aul, W. Schneider in Supportive Care in Cancer Patients II (1991)

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    Chapter and Conference Paper

    Regulation of Erythropoietin Production in Patients with Myelodysplastic Syndromes

    Preleukemic syndromes or myelodysplastic syndromes (MDS) comprise a heterogeneous group of acquired bone marrow disorders, probably resulting from malignant transformation of a multipotent hematopoietic stem c...

    C. Aul, A. Heyll, V. Runde, M. Arning, W. Schneider in Acute Leukemias (1992)

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    Chapter and Conference Paper

    Incidence and Severity of Amphotericin B-induced Acute Toxicity in Leukemic Patients After Treatment with Three Different Formulations (Amphotericin B, AmBisome and Amphotericin B/lntralipid) — A Pilot Study

    Intravenous amphotericin B (AmB) is the most potent drug for treatment of systemic fungal infections in leukemic patients. However, use of this drug is often limited by renal side effects and acute toxicity (f...

    M. Arning, K. O. Kliche, A. Wehmeier, A. H. Heer-Sonderhoff… in Acute Leukemias V (1996)

  5. No Access

    Chapter and Conference Paper

    Involvement of ICE-Like Proteases in Gemcitabine-Induced Programmed Cell Death

    Activation of ICE-like-protease cascade is a crucial step in Fas/APO-1 (CD95) induced apoptosis in different cell lines. Here we determined the role of interleukin-1 ß-converting enzyme (ICE) and CPP32/YAMA in...

    O. J. Stoetzer, A. Pogrebniak, V. Heinemann, U. Gullis, M. Darsow… in Acute Leukemias VII (1998)