36 Result(s)
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Chapter and Conference Paper
Genes Specifically Expressed in Monocytic AML Cells Identified by Array Technology
In this study we examined the expression pattern of monocytic acute myeloid leukemia (AML) blasts in comparison to monocytes from healthy donors using a cDNA array technology to identify differentially express...
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Chapter and Conference Paper
The CCC-assay: A new Assay for Characterization of Leukaemic Cells Surviving Chemotherapy in-vitro
Patients with acute myeloid leukemia (AML) are usually treated with polychemotherapy. The problem of minimal residual disease is obviously the reason for relapse and corresponds to a selection of drug resistan...
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Chapter and Conference Paper
Significance of AC133 and CD34 Expression on Acute Myeloid Leukemia Cells
AC 133 is a novel monoclonal antibody that recognizes a CD34bright subset of human progenitor cells (Yin et al, 1997). Very little data exists so far on expression of AC 133 on leukemic blasts. This seems impo...
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Chapter and Conference Paper
Prognostic Relevance of In-Vitro Drug Sensitivity Testing in Adult AML
The prognostic accuracy ofin-vitro drug sensitivity tests such as the differential staining cytotoxicity (DISC) assay must be assessed by correlation with response rates and also patient survival. We prospectivel...
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Chapter and Conference Paper
Predictive Value of Pretherapeutic In-Vitro Chemosensitivity Testing in Adult AML
Individual prognosis in adult AML may still not be determined by known prognostic factors, e.g. age, cytogenetics. Short term in-vitro drug sensitivity tests such as the differential staining cytotoxicity (DIS...
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Chapter and Conference Paper
Immunomodulation and Therapeutic Effects of a Monotherapy with Interleukin-2 as an Induction Therapy in Patients with Poor-Prognosis Acute Myeloid Leukemia
IL-2 has been shown to induce several mechanisms of MHC-restricted and MHC-unrestricted cytotoxicity against leukemic blasts in vitro and in vivo. Also it is known that patients with AML have a reduced or defe...
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Chapter and Conference Paper
Phase II Trial of Idarubicin, Fludarabine, Cytosine Arabinoside and Filgrastim (G-CSF) for Treatment of Refractory, Relapsed, and Secondary Acute Myeloid Leukemia
The combination of fludarabine and cytosine arabinoside (ara-C) with a simultaneous infusion of granulocyte colony-stimulating factor (G-CSF; FLAG) is an effective chemotherapy to induce remission in poor-prog...
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Chapter and Conference Paper
Lack of Correlation Between Multi-Drug Resistance Expression and Clinical Response to Chemotherapy in Patients with Acute Myeloid Leukemia
Expression of the multi-drug-resistance (MDR) protein gpl70 encoded by the mdrl gene has been implied to play a role in acute myeloid leukemia (AML) refractory to chemotherapy. We investigated MDR expression b...
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Chapter and Conference Paper
DEXA-BEAM Salvage Chemotherapy and High-Dose Chemotherapy Followed by Autologous Bone Marrow Transplantation in Hodgkin’s Disease
Patients with advanced stage Hodgkin’s disease (HD) who fail first-line therapy or relapse within the first 12 months after having achieved a complete remission with combination chemotherapy (and radiotherapy)...
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Chapter and Conference Paper
Low-Dose Cytosine Arabinoside Regimen Adapted to the FAB Classifications of Myelodysplastic Syndromes: Is it Superior to Uniform Treatment for all Types of MDS?
Low doses of cytosine arabinoside (ara-C) have been widely used in advanced myelodysplastic syndromes (MDS) characterized by cytopenia and increasing requirement of supportive therapy since complete remissions...
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Chapter and Conference Paper
Clinical and Experimental Observations Concerning Treatment Planning in Mantle Field Irradiation
Clinically successful results with irradiation in Hodgkin’s disease using shaped fields for supra- and infradiaphragmatic treatment were first reported by Kaplan. Since that time the large field technique has ...
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Chapter and Conference Paper
Screening of 19 Monoclonal Antibodies for their Potential as Ricin A-Chain Immunotoxins Against Myeloid Leukemia Cell Lines
Second-generation ricin A-chain immunotoxins have better stability, higher purity, and home to the liver much less rapidly than their predecessors [1, 2]. They have been demonstrated in vitro and in vivo to ha...
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Chapter and Conference Paper
Cytokines in Hodgkin’s Disease
Hodgkin’s disease (HD) involves one of the very few tumors in which chemotherapy and/or radiotherapy can cure the patient in most instances. Also, the histological appearance is very special, and this is a rea...
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Chapter and Conference Paper
Pretherapeutic Drug Testing in Acute Leukemias for Prediction of Individual Prognosis
Treatment of patients with acute leukemia is usually based upon utilization of multidrug regimens. Although the response rates for AML and ALL are quite high, the therapeutic efficacy of a drug against an indi...
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Chapter and Conference Paper
Effect of Treatment with rhGM-CSF and Low-Dose Cytosine Arabinoside on Leukemic Blast Cells in Patients with Myelodysplastic Syndromes
Treatment of patients having myelodysplastic a syndromes (MDS) with approaches such as differentiation induction, single cytostatic agents or supportive care only has, up to now, been rather unsuccessful. Aggr...
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Chapter and Conference Paper
Expression of High Affinity IL-2 Receptors on a Hodgkin Cell Line
Recent data based on genetic analysis of immunoglobulin and T cell receptor gene rearrangements suggest that Hodgkin (H) and Sternberg-Reed (SR) cells have characteristics of lymphoid cells [3, 5, 19]. It has ...
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Chapter and Conference Paper
Biology of Hodgkin Cell Lines
Studies to characterize Hodgkin and Reed-Sternberg cells in histological sections have yielded many conflicting data over the years. Even with progress in immunohistological technology, the histogenetic deriva...
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Chapter and Conference Paper
Diagnostic Strategies and Staging Procedures for Hodgkin’s Lymphoma: Bone Marrow Scintigraphy and Magnetic Resonance Imaging
In Hodgkin's lymphoma the bone marrow is infrequently involved. Clinical diagnosis is usually made by bone marrow biopsy. Because biopsy is blind, false-negative results often occur. For imaging of the bone ma...
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Chapter and Conference Paper
Conventional Salvage Therapy for Hodgkin’s Lymphoma
High remission rates are obtained in advanced Hodgkin’s lymphoma utilizing combination chemotherapy such as MOPP (mustargen, vincristine, procarbazine, and prednisone) (DeVita et al. 1970; Longo et al. 1986) a...
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Chapter and Conference Paper
Bone Marrow Transplantation in the Treatment of Hodgkin’s Lymphoma: Problems, Remaining Challenges, and Future Prospects
Table 1 summarizes the results of autologous bone marrow transplantation (ABMT) in more than 200 patients. The results seem to be rather consistent between the groups who have the largest published series of A...
