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Article
Open AccessInsulin eye drops for severe refractory chronic ocular graft-versus-host disease
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Article
Sequential vs myeloablative vs reduced intensity conditioning for patients with myelodysplastic syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: a retrospective study by the chronic malignancies working party of the EBMT
The optimal conditioning for patients with higher risk MDS receiving potentially curative allogeneic haematopoietic stem cell transplant(allo-HCT) remains to be defined. This is particularly the case for patie...
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Article
Adverse environmental conditions are a risk factor for ocular GvHD after allogeneic hematopoietic stem cell transplantation
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Article
Bortezomib before and after high-dose therapy in myeloma: long-term results from the phase III HOVON-65/GMMG-HD4 trial
The Dutch-Belgian Cooperative Trial Group for Hematology Oncology Group-65/German-speaking Myeloma Multicenter Group-HD4 (HOVON-65/GMMG-HD4) phase III trial compared bortezomib (BTZ) before and after high-dose...
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Article
Impact of choice, timing, sequence and combination of broad-spectrum antibiotics on the outcome of allogeneic haematopoietic stem cell transplantation
Recent data link the incidence of intestinal GvHD (iGvHD) after allogeneic haematopoietic stem cell transplantation (aSCT) to exposure with piperacillin–tazobactam or imipenem–cilastatin. To assess relevance o...
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Article
Open AccessValidation of the revised IPSS at transplant in patients with myelodysplastic syndrome/transformed acute myelogenous leukemia receiving allogeneic stem cell transplantation: a retrospective analysis of the EBMT chronic malignancies working party
The International Prognostic Scoring System has been revised (IPSS-R) to predict prognosis of patients with myelodysplastic syndromes at diagnosis. To validate the use of the IPSS-R assessed before transplant ...
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Article
Open AccessAssessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants
Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytar...
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Article
Besonderheiten beim elektiven Hüftgelenkersatz des älteren Menschen
Aufgrund des demografischen Wandels wird eine zunehmend größere Anzahl von Patienten im fortgeschrittenen Lebensalter mit einer Hüfttotalendoprothese versorgt. Um eine sichere Versorgung des älteren Patienten ...
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Chapter
Transplantationsmedizin in der Intensivmedizin
Die Betreuung von Patienten vor und nach einer Organtransplantation gehört zum Gebiet der „speziellen Intensivmedizin“ des jeweiligen Fachbereichs. Die transplantationsspezifische Intensivmedizin setzt daher e...
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Article
Nekrotisierende Fasziitis – eine klinische Diagnose
Die nekrotisierende Fasziitis ist ein lebensbedrohliches Krankheitsbild, welches bei verzögerter Diagnostik und inadäquater Therapie zu Multiorganversagen und Tod führt. Wir berichten im Folgenden von einem 68...
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Article
Open AccessLong-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment
Tyrosine kinase inhibitors represent today’s treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective ra...
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Article
Nonmyeloablative allogeneic stem cell transplantation for chronic lymphocytic leukaemia offers the possibility of disease control with minimal morbidity and mortality—a single institution experience
Allogeneic stem cell transplantation is a treatment option for patients with poor risk CLL. We conducted a retrospective analysis of all CLL patients allografted at our institution, the University Hospital of ...
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Article
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
Despite major improvements in allogeneic hematopoietic cell transplantation over the past decades, corticosteroid-refractory (SR) acute (a) and chronic (c) graft-versus-host disease (GVHD) cause high mortality...
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Article
Phase III trial of bortezomib, cyclophosphamide and dexamethasone (VCD) versus bortezomib, doxorubicin and dexamethasone (PAd) in newly diagnosed myeloma
We aimed at demonstrating non-inferiority of bortezomib/cyclophosphamide/dexamethasone (VCD) compared to bortezomib/doxorubicin/dexamethasone (PAd) induction therapy with respect to very good partial response ...
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Article
Meibography and meibomian gland measurements in ocular graft-versus-host disease
Meibomian gland loss in ocular GvHD was described as a mechanism contributing to dry eye and severe damage to the ocular surface. Infrared images of upper eyelid meibomian glands from 86 ocular GvHD patients, ...
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Article
Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV
Tyrosine kinase inhibitors (TKI) have changed the natural course of chronic myeloid leukemia (CML). With the advent of second-generation TKI safety and efficacy issues have gained interest. The randomized CML ...
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Article
Transplantation hämatopoetischer Stammzellen
Die Zahl der Stammzelltransplantationen in Deutschland nimmt seit Jahren stetig zu. Patienten mit höherem Lebensalter und umfassenden Begleiterkrankungen werden deutlich häufiger in kurativer Intention einer T...
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Article
Optimization of health-care organization and perceived improvement of patient comfort by switching from intra-venous BU four-times-daily infusions to a once-daily administration scheme in adult hematopoietic stem cell recipients
Previous studies have shown an equivalent pharmacokinetic profile between four-times-daily (4QD) and once-daily (QD) administration of intra-venous (IV) BU, without increased toxicity. We assess the impact of ...
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Chapter and Conference Paper
A-Priori Convergence Analysis of a Discontinuous Galerkin Time-Domain Method to Solve Maxwell’s Equations on Hybrid Meshes
We study a multi-element Discontinuous Galerkin Time Domain (DGTD) method for solving the system of unsteady Maxwell equations. This method is formulated on a non-conforming and hybrid mesh combining a structu...
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Article
Plerixafor for PBSC mobilisation in myeloma patients with advanced renal failure: safety and efficacy data in a series of 21 patients from Europe and the USA
We describe 20 patients with myeloma and 1 with primary amyloidosis from 15 centres, all with advanced renal failure, most of whom had PBSC mobilised using plerixafor following previous failed mobilisation by ...