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  1. No Access

    Article

    Retargeting adenoviral vectors to improve gene transfer into tumors

    Gene targeting to tumors using adenoviral (Ad) vectors holds great potential for cancer imaging and therapy, but the limited efficacy of current methods used to improve delivery to target tissues and reduce un...

    R T Hogg, P Thorpe, R D Gerard in Cancer Gene Therapy (2011)

  2. No Access

    Article

    The outcome of Direct Current Cardioversion (DCC) for the treatment of Atrial Fibrillation (AF) in a district general hospital in Ireland

    Direct current cardioversion (DCC) is a method to control persistent AF, to facilitate a reduction in stroke risk. Although this is a frequently performed procedure, there are no available published data regar...

    K. P. O’Rourke, C. Cotter, D. Mullane, P. Thorpe… in Irish Journal of Medical Science (2006)

  3. No Access

    Article

    Spontaneous life-threatening perirenal haemorrhage: an uncommon urological emergency

    Spontaneous perirenal haemorrhage is a rare but potentially life-threatening condition and requires urgent management. Diagnosis is based on clinical assessment combined with radiological investigations, as re...

    B K Somani, G Nabi, P Thorpe, S Swami in Emergency Radiology (2005)

  4. No Access

    Article

    Wireless LANs — Present and Future

    Wireless LAN technology has grown rapidly in importance over the last two years, because it fills a real user need at a cost the user can afford. This paper firstly provides a brief description of the main tec...

    L Burness, D Higgins, A Sago, P Thorpe in BT Technology Journal (2003)

  5. Article

    Open Access

    Purified malignant mammary epithelial cells maintain hormone responsiveness in culture

    Currently, the therapy for breast cancer is determined by immunohistochemical staining of the primary tumour for oestrogen receptor alpha (ERα). However, a proportion of ERα-positive patients fail to respond to t...

    M S Kothari, S Ali, L Buluwela, N Livni, S Shousha… in British Journal of Cancer (2003)

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  6. No Access

    Article

    Optimising gene repair strategies in cell culture

    Gene repair, the precise modification of the genome, offers a number of advantages over replacement gene therapy. In practice, gene targeting strategies are limited by the inefficiency of homologous recombinat...

    P Thorpe, B J Stevenson, D J Porteous in Gene Therapy (2002)

  7. No Access

    Chapter

    Commercial applications of performance monitoring

    As outlined in the foregoing chapters of this section of the handbook, performance monitoring is normally undertaken to ensure that an item of equipment or machinery is operating correctly, to a required stand...

    A. Davies, K. F. Martin, P. Thorpe in Handbook of Condition Monitoring (1998)

  8. No Access

    Article

    Immunotoxins against the vasculature of human Hodgkin’s lymphoma in SCID mice

    D. Schiefer, R. Schnell, C. Gottstein… in Journal of Cancer Research and Clinical On… (1995)

  9. No Access

    Chapter and Conference Paper

    Screening of 19 Monoclonal Antibodies for their Potential as Ricin A-Chain Immunotoxins Against Myeloid Leukemia Cell Lines

    Second-generation ricin A-chain immunotoxins have better stability, higher purity, and home to the liver much less rapidly than their predecessors [1, 2]. They have been demonstrated in vitro and in vivo to ha...

    A. Engert, A. Brown, V. Diehl, P. Thorpe in Acute Leukemias (1992)

  10. No Access

    Article

    Coolant system health monitoring and fault diagnosis via health parameters and fault dictionary

    A new methodology is described for the condition monitoring and fault diagnosis of machine tool coolant systems. The steady state characteristics of the coolant system pump outlet pressure, pump motor temperat...

    K. F. Martin, P. Thorpe in The International Journal of Advanced Manufacturing Technology (1990)