12 Result(s)
within
Chapter
Mitsuru Akashi
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Chapter
Fabrication Methods of Sustainable Hydrogels
The interest received on hydrogels probably reflects one of the greatest challenges for the two last decades. Able to hold and release solvents and builds, these three-dimensional polymeric structures work as ...
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Chapter
Development of Full-Thickness Human Skin Equivalents with Blood and Lymph-like Capillary Networks by Cell Coating Technology
We developed a human skin equivalent (HSE) containing blood and lymph-like capillary networks using a cell-coating technique. This technique is a rapid fabrication technology of three-dimensional cellular cons...
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Chapter
Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
Polymeric nano- and microparticles have recently been shown to possess significant potential as drug delivery systems. In particular, the use of biodegradable polymeric nanoparticles with entrapped antigens su...
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Chapter
Pharmaceutical and Medical Applications of Poly-Gamma-Glutamic Acid
Poly(amino acid)s have received considerable attention for biomedical applications. Poly(γ-glutamic acid) (γ-PGA), a natural polymer, is synthesized by several gram-positive bacteria. γ-PGA is anionic, water s...
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Chapter and Conference Paper
Surface Modification Techniques for the Artificial Heart
We evaluated different surface modification techniques for polymeric materials used in the artificial heart. Proposed approaches to design nonthrombogenic polymer surfaces include (1) phase-separated micro-dom...
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Chapter and Conference Paper
Estimation of Biocompatibility of Polymeric Materials Using RT-PCR Method
One of the most important factors in determining biocompatibility is the cellular response at the tissue-biomaterial interface. In this study, we would introduce a novel research method for the estimation of b...
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Chapter and Conference Paper
Immobilization of Human Thrombomodulin Onto Biomaterials: Evaluation of Antithrombogenicity Using Small Dialyzer
Thrombomodulin (TM) is a newly described endothelial cell associated protein. In this study, focusing on the establishment of the practical evaluation of the hTM-immobilized materials, a novel testing systems ...
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Chapter and Conference Paper
A Novel Biomateral: Aramid-Silicone Resin
Aramid-silicone resins (PASs) consisting of aromatic polyamide (aramid) and poly (dimethyl-siloxane) (PDMS) segments were synthesized by low temperature solution polycondensation. Using 3-bis(3-aminopropyl)-1,...
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Chapter and Conference Paper
Adsorption of Biomolecules onto Multiblock Copolymer Consisting of Aromatic Polyamide and Poly(Dimethylsiloxane)
Multiblock copolymer(Aramid-Silicone Resin; PAS) consisting of aromatic polyamide(aramid) and poly(dimethylsiloxane)(PDMS) has desirable properties of both components. In this study, we investigated the protei...
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Chapter and Conference Paper
Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer
Previously, we found that the sulfonated poly(glucosyloxyethyl methacrylate) (poly(GEMA)-sulfate), which bears sulfonated D-(+)-glucose, had anticoagulant activity. In this study, we tried to clarify the mecha...
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Chapter and Conference Paper
Antithrombogenic Biomaterials. Poly(Vinyl Chloride) with Heparin-and/or PGI2-Immobilized in Hydrogels and Thrombomodulin-Immobilized Beads.
The luminal surface of blood vessels is covered with endothelium which possesses various antithrombogenic functions and maintain blood fluidity. The anti-thrombogenic functions include the production of PGI2, the...
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Chapter and Conference Paper
New aspects of polymer drugs
This article reviews results on the studies of biomedical applications of functional polymers in which biologically active compounds are chemically or physically immobilized. The strategy for achieving of biol...
