255 Result(s)
within
Biomedicine
Pharmacology/Toxicology
Ke** Zhang
Chapter
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Synthetic Polymers for HME-Based 3D Printing
This chapter focuses on synthetic polymers that have been used either individually or in combination as the matrix materials or plasticizers for fused deposition modeling (FDM) 3D printing. The polymers used f...
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Microfluidics for Formulation and Scale-Up Production of Nanoparticles for Biopharma Industry
The biopharmaceutical market is undergoing rapid growth, particularly in the realm of nanomedicine, where nanoparticles containing biologics are prevalent. The success of this market is exemplified by proven i...
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Semisolid Extrusion Printing and 3D Bioprinting
This chapter provides an insightful overview of two transformative technologies in the realm of additive manufacturing: semisolid extrusion printing (SEP) and 3D bioprinting. Semisolid extrusion printing, a no...
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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+ ions across the cellular membranes, but the physiological process...
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Neurotoxicity of Aluminum and Its Compound Nanoparticles
The rapid development of nanotechnology has led to the emergence of new nanomaterials. Due to their special physicochemical properties, such as smaller size, larger specific surface area, and higher reactivity...
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The Short QT Syndrome
The short QT syndrome (SQTS) is characterised by abbreviated QT intervals on the electrocardiogram and by an increased risk of atrial and ventricular arrhythmias and of sudden death. Gain-of-function mutations...
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The Recent Development of Therapeutic Strategies Against COVID-19
In the past years, an emerging coronavirus, namely severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused the pandemic of coronavirus disease 2019 (COVID-19), which led to a serious public he...
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Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism
Aluminum, an environmentally abundant non-redox trivalent cation, has long been reported to alter blood-brain barrier and gets deposited in different regions of the brain. Many reports strongly indicated that ...
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Aluminum-Induced Neural Cell Death
Aluminum (Al), an abundant element in the Earth’s crust, is well known for its neurotoxicity. Nonetheless, its causal role in neurodegenerative diseases, particularly in Alzheimer’s disease (AD), is still unde...
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Alumina Nanoparticles Induced Neurotoxic and Neurodevelopmental Toxic Effects
Nano-alumina (AlNPs) is widely used because of its unique physicochemical properties. AlNPs can be released directly or indirectly into the environment, causing extensive exposure and potential harm to humans....
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Aquaporins in Reproductive System
AQP0-12, a total of 13 aquaporins are expressed in the mammalian reproductive system. These aquaporins mediate the transport of water and small solutes across biofilms for maintaining reproductive tract water ...
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Melt Extrusion
Techniques to overcome poor aqueous solubility of active pharmaceutical ingredients (APIs) continue to gain interest, with a reported 30% of marketed compounds classified as BCS II and 10% classified as BCS IV...
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Mechanisms for the Sour Taste
Sour, the taste of acids, provides important sensory information to prevent the ingestion of unripe, spoiled, or fermented foods. In mammals, acids elicit disgust and pain by simultaneously activating taste an...
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Tumor-Associated Macrophages: Therapeutic Targets of Cancer
It has been widely known that macrophages play critical roles during infection and immune responses. While as tumor-infiltrating myeloid cells, macrophages accumulated in the tumor microenvironment (TME) could...
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Effects of Nutrients/Nutrition on Toxicants/Toxicity
There is no doubt that food components can interact with mammal’s biological functions. Nutrients or nutritional metabolism in the body can influence the cytochrome P450, leading to biochemical changes. The ca...
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HDL and Lipid Metabolism
Mediating reverse cholesterol transport (RCT) is the most classic function of HDL. HDL and HDL-C participate in the entire process of RCT, including cholesterol removal from cells, cholesterol transport in cir...
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Risk Assessment and Risk-Benefit Assessment
The framework of risk analysis has become the principal procedure for dealing with food safety issues. Risk analysis consists of three components: risk management, risk assessment, and risk communication, whil...
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Tolerable Upper Limits of Nutrients
Unlike non-nutrients, the risk for nutrient substances will increase with both inadequate and excessive intakes when homeostatic balance is broken in human bodies. Upper level of intake (UL) is the maximum lev...
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TLR Signaling in Brain Immunity
Toll-like receptors (TLRs) comprise a group of transmembrane proteins with crucial roles in pathogen recognition, immune responses, and signal transduction. This family represented the first line of immune hom...
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HDL and Oxidation
In this chapter, we will focus on HDLs’ activity of inhibiting LDL oxidation and neutralizing some other oxidants. ApoA-I was known as the main antioxidant component in HDLs. The regulation of antioxidant capa...
