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Chapter and Conference Paper
RPGRIP1 and Cone–Rod Dystrophy in Dogs
Cone–rod dystrophies (crd) represent a group of progressive inherited blinding diseases characterized by primary dysfunction and loss of cone photoreceptors accompanying or preceding rod death. Recessive crd type...
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Chapter and Conference Paper
Modeling the Structural Consequences of BEST1 Missense Mutations
Mutations in the bestrophin-1 gene (BEST1) are an important cause of inherited retinal disorders. Hitherto, over 100 unique allelic variants have been linked to the human BEST1 (hBEST1), and associated with disea...
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Chapter
Characterization of Gene Expression Profiles of Normal Canine Retina and Brain Using a Retinal cDNA Microarray
Microarrays have been useful in the simultaneous analysis of transcript levels of thousands of genes in different physiological states of an organism, tissue or cell (Shalon et al., 1996; Schena et al., 1996)....
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Chapter
The Use of Imperfect Microsatellites for DNA Fingerprinting and Population Genetics
Since their introduction about 10 years ago, microsatellites have been demonstrated to be a powerful tool for genetic analysis of natural populations [1]. Microsatellites are easy to isolate, highly polymorphi...