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    Chapter

    Origin of new genes: evidence from experimental and computational analyses

    Exon shuffling is an essential molecular mechanism for the formation of new genes. Many cases of exon shuffling have been reported in vertebrate genes. These discoveries revealed the importance of exon shuffli...

    Manyuan Long, Michael Deutsch, Wen Wang in Origin and Evolution of New Gene Functions (2003)

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    Chapter

    Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics

    Current insulin formulations do not mimic the normal glucose-induced release of insulin by the pancreas in a physiological manner.1 One limitation is the delayed absorption of hexameric insulin from the subcutane...

    Lawrence J. Slieker, Gerald S. Brooke in Current Directions in Insulin-Like Growth … (1993)

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    Chapter

    Protein C: Gene Structure and Protein Synthesis

    Protein C is a vitamin K-dependent plasma glycoprotein that, after activation by thrombin-thrombomodulin upon the endothelial cell surface, serves as a feedback down-regulator of the coagulation cascade by spe...

    George L. Long in Recombinant Technology in Hemostasis and Thrombosis (1991)

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    Chapter

    Genetic Aspects of Symbiotic Nitrogen Fixation

    Nitrogen fixation is the reduction of molecular dinitrogen (N2) to ammonia. This process, along with nitrate reduction, brings nitrogen from inorganic form into the organic world, for ammonia is the form of nitro...

    Sharon R. Long in Gene Manipulation in Plant Improvement (1984)