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The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
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Preliminary field validity of ActiGraph-based energy expenditure estimation in wheelchair users with spinal cord injury
Study designCross-sectional validation study.
ObjectivesTo develop a raw acceleration signal-based random forest (RF) model for predicting total...
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Integrating brain function and structure in the study of the human attentional networks: a functionnectome study
Attention is a heterogeneous function theoretically divided into different systems. While functional magnetic resonance imaging (fMRI) has...
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Microstructural properties in subacute aphasia: concurrent and prospective relationships underpinning recovery
Background: Few investigations examined the relationship between microstructural white matter integrity and subacute post-stroke linguistic...
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Constraining current neuroanatomical models of reading: the view from Arabic
There is a growing interest in imaging understudied orthographies to unravel their neuronal correlates and their implications for existing...
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The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases
Neurodegenerative diseases pose a significant health challenge for the elderly. The escalating presence of toxic metals and chemicals in the...
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miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization
BackgroundColorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present...
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From Gut Microbiomes to Infectious Pathogens: Neurological Disease Game Changers
Gut microbiota and infectious diseases affect neurological disorders, brain development, and function. Compounds generated in the gastrointestinal...
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Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Persistent sodium current (I NaP ) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of physiological...
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Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors
The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component of normal and pathological tissues of the embryo and...
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Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
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A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular biology and regenerative...
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Unraveling metabolic pathways and key genes in Alzheimer’s, type 2 diabetes, and estrogen dysregulation among aging women: a systems biology approach
BackgroundAlzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) present significant global health challenges, particularly affecting aging...
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Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant...
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The interplay between microRNAs and Nrf2 signaling in human cancers
MicroRNAs (miRNAs), as a class of nonprotein-coding RNAs, post-transcriptionally regulate the expression of target genes by base pairing to...
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The Role of the Neural Exposome as a Novel Strategy to Identify and Mitigate Health Inequities in Alzheimer’s Disease and Related Dementias
With the continuous increase of the elderly population, there is an urgency to understand and develop relevant treatments for Alzheimer’s disease and...
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Characterizing the Linkage of Systemic Hypoxia and Angiogenesis in High-Grade Glioma to Define the Changes in Tumor Microenvironment for Predicting Prognosis
High-grade gliomas (HGG) comprising WHO grades 3 and 4 have a poor overall survival (OS) that has not improved in the past decade. Herein, markers...
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The role of lncRNA NEAT1 in human cancer chemoresistance
Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for...
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Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are mainly caused by mosaic...
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Association between Ultradian Rhythms of Body Temperature in Small Mammals and Earth’s Crust Stress
Association was assessed between the data harvested by a long-baseline laser interference deformograph and the dynamics of body temperature (BT) in...