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The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases

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Abstract

Neurodegenerative diseases pose a significant health challenge for the elderly. The escalating presence of toxic metals and chemicals in the environment is a potential contributor to central nervous system dysfunction and the onset of neurodegenerative conditions. Transition metals play a crucial role in various pathophysiological mechanisms associated with prevalent neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Given the ubiquitous exposure to metals from diverse sources in everyday life, the workplace, and the environment, most of the population faces regular contact with different forms of these metals. Disturbances in the levels and homeostasis of certain transition metals are closely linked to the manifestation of neurodegenerative disorders. Oxidative damage further exacerbates the progression of neurological consequences. Presently, there exists no curative therapy for individuals afflicted by neurodegenerative diseases, with treatment approaches primarily focusing on alleviating pathological symptoms. Within the realm of biologically active compounds derived from plants, flavonoids and curcuminoids stand out for their extensively documented antioxidant, antiplatelet, and neuroprotective properties. The utilization of these compounds holds the potential to formulate highly effective therapeutic strategies for managing neurodegenerative diseases. This review provides a comprehensive overview of the impact of abnormal metal levels, particularly copper, iron, and zinc, on the initiation and progression of neurodegenerative diseases. Additionally, it aims to elucidate the potential of fisetin and curcumin to inhibit or decelerate the neurodegenerative process.

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Authors and Affiliations

  1. Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo I Rana, Norway

    Geir Bjørklund

  2. Department of Disaster Medicine and Military Medicine, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine

    Petro Oliinyk

  3. CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine

    Petro Oliinyk, Oksana Khavrona, Iryna Lozynska, Roman Lysiuk, Roman Darmohray, Olha Antoniv & Oksana Rybak

  4. Department of Biological Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine

    Oksana Khavrona & Iryna Lozynska

  5. Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine

    Roman Lysiuk, Roman Darmohray & Oksana Rybak

  6. Department of Ecology, Ivan Franko National University of Lviv, Lviv, 79005, Ukraine

    Halyna Antonyak

  7. Andrei Krupynskyi Lviv Medical Academy, Lviv, 79000, Ukraine

    Natalia Dub

  8. Department of Botany, Ukrainian National Forestry University, Wood Science and Non-Wood Forest Products, Lviv, 79057, Ukraine

    Vasyl Zayachuk

  9. Department of Pharmacology, Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine

    Olha Antoniv

  10. Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100, Sassari, Italy

    Massimiliano Peana

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  1. Geir Bjørklund
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Contributions

G.B. and M.P. conceived the idea. G.B., P.O., O.K., I.L., R.L., R.D., H.A., N.D., V.Z., O.A., and O.R. edited the manuscript. G.B. and M.P. contributed to the final version of the manuscript. G.B. supervised the project. All authors have read and agreed to the published version of the manuscript.

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Bjørklund, G., Oliinyk, P., Khavrona, O. et al. The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases. Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04321-2

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