14 Result(s)
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Article
Yuri Motorin
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Article
Open AccessN1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer’s disease
One mechanism of particular interest to regulate mRNA fate post-transcriptionally is mRNA modification. Especially the extent of m1A mRNA methylation is highly discussed due to methodological differences. However...
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Open AccessQuantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is lacki...
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Open AccessMETTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome d...
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Open AccessFUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications
FUS is a multifunctional protein involved in many aspects of RNA metabolism, including transcription, splicing, translation, miRNA processing, and replication-dependent histone gene expression. In this work, w...
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Open AccessFTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Cancer stem cells (CSCs) are a small but critical cell population for cancer biology since they display inherent resistance to standard therapies and give rise to metastases. Despite accruing evidence establis...
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Open AccessCell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo
Recently, studies about RNA modification dynamics in human RNAs are among the most controversially discussed. As a main reason, we identified the unavailability of a technique which allows the investigation of...
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Open Access2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mus...
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Open AccessLimited antibody specificity compromises epitranscriptomic analyses
A controversial discussion on the occurrence of the RNA modification m1A in mRNA takes a new turn, as an antibody with a central role in modification map** was shown to also bind mRNA cap structures.
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FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing
In mammals, 2′-O-methylation of RNA is a molecular signature by which the cellular innate immune system distinguishes endogenous from exogenous messenger RNA1–3. However, the molecular functions of RNA 2′-O-methy...
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Open AccessContribution of protein Gar1 to the RNA-guided and RNA-independent rRNA:Ψ-synthase activities of the archaeal Cbf5 protein
Archaeal RNA:pseudouridine-synthase (PUS) Cbf5 in complex with proteins L7Ae, Nop10 and Gar1, and guide box H/ACA sRNAs forms ribonucleoprotein (RNP) catalysts that insure the conversion of uridines into pseud...
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Open AccessPublisher Correction: A PRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients
The original version of this Article contained an error in the title, which was incorrectly given as 'APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients'. This has now been corrected in b...
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Open AccessA PRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients
To date, epimutations reported in man have been somatic and erased in germlines. Here, we identify a cause of the autosomal recessive cblC class of inborn errors of vitamin B12 metabolism that we name “epi-cblC”....
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Open AccessIdentification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic map**
Ribosomal RNA modifications are important in optimizing ribosome function. Sugar 2′-O-methylation performed by fibrillarin-associated box C/D antisense guide snoRNAs impacts all steps of translation, playing a...
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Detecting RNA modifications in the epitranscriptome: predict and validate
Modified nucleotides are present in many RNA species and have multiple roles in the global regulation and fine-tuning of gene expression.
