146 Result(s)
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Article
Yung-** Chang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 1...
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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
Epidermal growth factor receptor, the product of a human oncogene, suppresses the maturation of specific tumour-suppressor-like microRNAs in response to hypoxic stress through phosphorylation of argonaute 2.
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Open AccessUltrahigh-Gain Photodetectors Based on Atomically Thin Graphene-MoS2 Heterostructures
Due to its high carrier mobility, broadband absorption and fast response time, the semi-metallic graphene is attractive for optoelectronics. Another two-dimensional semiconducting material molybdenum disulfide...
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Open AccessIn situ observation of step-edge in-plane growth of graphene in a STEM
It is extremely difficult to control the growth orientation of the graphene layer in comparison to Si or III–V semiconductors. Here we report a direct observation of graphene growth and domain boundary formati...
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Open AccessThe effect of fluorescent nanodiamonds on neuronal survival and morphogenesis
Nanodiamond (ND) has emerged as a promising carbon nanomaterial for therapeutic applications. In previous studies, ND has been reported to have outstanding biocompatibility and high uptake rate in various cell...
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Open AccessAchieving planar plasmonic subwavelength resolution using alternately arranged insulator-metal and insulator-insulator-metal composite structures
This work develops and analyzes a planar subwavelength device with the ability of one-dimensional resolution at visible frequencies that is based on alternately arranged insulator-metal (IM) and insulator-insu...
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Open AccessSirtinol Inhibits Neutrophil Elastase Activity and Attenuates Lipopolysaccharide-Mediated Acute Lung Injury in Mice
Enhanced activity of neutrophil elastase leads to a protease–antiprotease imbalance and plays an essential pathogenic role in acute lung injury (ALI) and acute respiratory distress syndrome. We assayed the pha...
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IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection
Th1 cells control their activity by producing regulatory IL-10. Here we report that Th1 cell-derived IL-10 facilitates their expansion and, in addition, augments Th1 cell production of IFN-γ, TNF-α and IL-2 du...
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Open AccessThree-fold rotational defects in two-dimensional transition metal dichalcogenides
As defects frequently govern the properties of crystalline solids, the precise microscopic knowledge of defect atomic structure is of fundamental importance. We report a new class of point defects in single-la...
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Open AccessA hybrid-membrane migration method to isolate high-purity adipose-derived stem cells from fat tissues
Human adipose-derived stem cells (hADSCs) exhibit heterogeneous characteristics, indicating various genotypes and differentiation abilities. The isolated hADSCs can possess different purity levels and divergen...
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Open AccessNonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress
The antiapoptotic and antiautophagic abilities of cancer cells constitute a major challenge for anticancer drug treatment. Strategies for triggering nonapoptotic or nonautophagic cell death may improve therape...
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Open AccessCharacterization of proteins regulated by interleukin-4 in 3T3-L1 adipocytes
Obesity is closely associated with metabolic syndrome, type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Our previous reports uncover the significant associations between interleukin-4 (IL-4)/IL-4 rece...
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Open AccessHomology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification
The inhibition of FMS-like tyrosine kinase 3 (FLT3) activity using small-molecule inhibitors has emerged as a target-based alternative to traditional chemotherapy for the treatment of acute myeloid leukemia (A...
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Open AccessApoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer
TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ population of tumor-infil...
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Open AccessMagnetically controlled planar hyperbolic metamaterials for subwavelength resolution
Breaking diffraction limitation is one of the most important issues and still remains to be solved for the demand of high-density optoelectronic components, especially for the photolithography industry. Since ...
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Open AccessGrowing GaN LEDs on amorphous SiC buffer with variable C/Si compositions
The epitaxy of high-power gallium nitride (GaN) light-emitting diode (LED) on amorphous silicon carbide (a-SixC1−x) buffer is demonstrated. The a-SixC1−x buffers with different nonstoichiometric C/Si composition ...
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Open AccessWhole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira
Leptospirosis, caused by pathogenic Leptospira spp., has recently been recognized as an emerging infectious disease worldwide. Despite its severity and global importance, knowledge about the molecular pathogenesi...
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Open AccessThermoelectric Power in Bilayer Graphene Device with Ionic Liquid Gating
The quest for materials showing large thermoelectric power has long been one of the important subjects in material science and technology. Such materials have great potential for thermoelectric cooling and als...
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Open AccessAcute Kidney Injury Classification for Critically Ill Cirrhotic Patients: A Comparison of the KDIGO, AKIN and RIFLE Classifications
Critically ill cirrhotic patients have high mortality rates, particularly when they present with acute kidney injury (AKI) on admission. The Kidney Disease: Improving Global Outcomes (KDIGO) group aimed to sta...
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Open AccessHelical Majorana fermions in -wave topological superconductivity of doped correlated quantum spin Hall insulators
There has been growing interest in searching for exotic self-conjugate, charge-neutral low-energy fermionic quasi-particles, known as Majorana fermions (MFs) in solid state systems. Their signatures have been ...
