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Article
Open AccessGRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3 (GRK3) is critical for GPCR signaling. Our genomic analysis showed that GRK3 expression correlated...
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Article
Open AccessPatient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma
Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and met...
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Article
Open AccessCorrection to: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessAuthor Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
Triple-negative breast cancer (TNBC), which lacks estrogen receptor α (ERα), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression, is closely related to basal-like breast cance...
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Article
Open AccessLncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma
PVT1 has emerged as an oncogene in many tumor types. However, its role in Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unknown. The aim of this study was to assess the role of PVT1 in BE/EAC...
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Article
Open AccessAuthor Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
The original version of this Article contained errors in the author affiliations. Qingnan Zhao, Xueqing **a, Longfei Huo and Shulin Li were incorrectly associated with Bei**g Institute for Brain Disorders, 10...
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Article
Open AccessFGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and pri...
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Protocol
Biochemical Fractionation of Membrane Receptors in the Nucleus
Fractionation of cytoplasmic and nuclear proteins is a well-recognized biochemical technique to detect the intracellular distribution and expression level of proteins of interest. In the last decade, accumulat...
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Article
Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells
Pancreatic cancer (PaCa) is one of the most aggressive, apoptosis-resistant and currently incurable cancers with a poor survival rate. Eukaryotic elongation factor-2 kinase (eEF-2K) is an atypical kinase, whos...
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Article
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
Epidermal growth factor receptor, the product of a human oncogene, suppresses the maturation of specific tumour-suppressor-like microRNAs in response to hypoxic stress through phosphorylation of argonaute 2.
