200 Result(s)

Article

Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155

Chronic kidney disease (CKD) is highly prevalent worldwide, and its global burden is substantial and growing. CKD displays a number of features of accelerated senescence. Tubular cell senescence is a common bi...

Qing Yin, Tao-Tao Tang, **ao-Yu Lu, Wei-Jie Ni, Di Yin… in Cell Communication and Signaling (2024)

Article

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...

Jian Gu, **aozhang Xu, **angyu Li, Lei Yue, **aowen Zhu, Qiuyang Chen, Ji Gao… in Oncogene (2024)

Article

Prostaglandin I₂ signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice

Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I₂ (PGI₂) can prevent the process of fibrosis in various tissue...

Yue Zhang, Meng Yuan, Wenbin Cai, Weiyan Sun… in Cellular and Molecular Life Sciences (2024)

Article

A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles

Physiologically, the atria contract first, followed by the ventricles, which is the prerequisite for normal blood circulation. The above phenomenon of atrioventricular sequential contraction results from the c...

Dandan Liang, Li** Zhou, Huixing Zhou, Fulei Zhang, Guojian Fang… in Cell Research (2024)

Article

Cell wall remodeling promotes callus formation in poplar

Geng Zhang, Peipei Liu, Guifang Zhang, **aomin Yao, **nwei Wang… in Molecular Horticulture (2024)

Article

Adipose-derived stem cells promote glycolysis and peritoneal metastasis via TGF-β1/SMAD3/ANGPTL4 axis in colorectal cancer

Peritoneal metastasis, the third most common metastasis in colorectal cancer (CRC), has a poor prognosis for the rapid progression and limited therapeutic strategy. However, the molecular characteristics and p...

Chaojun Zhu, Lan Teng, Yihong Lai, **ngxing Yao… in Cellular and Molecular Life Sciences (2024)

Article

Anoikis-related signature predicts prognosis and characterizes immune landscape of ovarian cancer

Ovarian cancer (OV) is the most lethal gynecological malignancy worldwide, with high recurrence rates. Anoikis, a newly-acknowledged form of programmed cell death, plays an essential role in cancer progression...

Jiani Yang, Yue Zhang, Shanshan Cheng, Yanna Xu, Meixuan Wu… in Cancer Cell International (2024)

Article

Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling

Exercise can promote adult neurogenesis and improve symptoms associated with schizophrenia and other mental disorders via parvalbumin (PV)-positive GABAergic interneurons in the dentate gyrus ErbB4 is the rece...

Yandong Yi, Yue** Zhang, Yuanlong Song, Yisheng Lu in Cellular and Molecular Neurobiology (2024)

Article

14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer

Over the past decade, the role of the 14–3-3 protein has received increasing interest. Seven subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its specificity. The 14–3-3ε prot...

Yue Zhang, Man Yan, Yongjun Yu, Jiang** Wang… in Cell Communication and Signaling (2024)

Article

Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation

Liver metastasis is the major reason for most of colorectal cancer (CRC) related deaths. Accumulating evidence indicates that CRC patients with non-alcoholic fatty liver disease (NAFLD) are at a greater risk o...

Chi Zhang, Yue Zhang, Yan Dong, Ruiyang Zi, Yijie Wang… in Cell Death Discovery (2024)

Article

Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway

Venetoclax, an inhibitor that selectively targets B cell lymphoma-2 (BCL-2) that has been approved for treating adult acute myeloid leukemia (AML) in combination with hypomethylating agents. However, its short...

**bao Yu, Yan Wang, Jiaxiong Tan, Yuchen Li, Pengyue Yang, Xuan Liu… in Cell Death Discovery (2024)

Article

New insights into the stemness of adoptively transferred T cells by γc family cytokines

T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in hematologic malignancies. It relie...

Mengshi Luo, Wenjian Gong, Yuewen Zhang, Huayi Li… in Cell Communication and Signaling (2023)

Article

Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme

Yueyue Zhang, Mengxue Xu, Po Wang, Jiahui Zhou, Guangxian Wang… in Cell Research (2023)