40 Result(s)
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Article
Yi-fan Chen
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Article
Open AccessTargeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function
Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated wi...
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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targetin...
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High-temperature polymer-based nanocomposites for high energy storage performance with robust cycling stability
High-power capacitors are highly demanded in advanced electronics and power systems, where rising concerns on the operating temperatures have evoked the attention on develo** highly reliable high-temperature...
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Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells
Neddylation is a type of posttranslational protein modification that has been observed to be overactivated in various cancers. UBC12 is one of two key E2 enzymes in the neddylation pathway. Reports indicate th...
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Lizhong Decoction Ameliorates Ulcerative Colitis in Mice via Regulation of Plasma and Urine Metabolic Profiling
To elucidate the mechanism of Lizhong Decoction (LZD) in treating dextran sodium sulfate (DSS)-induced colitis in mice based on metabonomics.
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Network reliability evaluation of manufacturing systems by using a deep learning approach
A manufacturing system with reworking actions is constructed as a stochastic-flow manufacturing networks (SFMN) because components (arcs and nodes) are with multi-state capacity. Network reliability is a usefu...
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Open AccessRibonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuS...
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Open AccessComparison of blood loss between tranexamic acid-soaked absorbable Gelfoam and topical retrograde injection via drainage catheter plus clam** in cervical laminoplasty surgery
To compare the safety and efficacy of tranexamic acid (TXA)-soaked absorbable Gelfoam and the retrograde injection of TXA through a drain with drain-clam** in degenerative cervical laminoplasty patients.
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Lambda binding energies in the Skyrme-Hartree-Fock approach with various \(\Lambda N\) interactions
The Lambda binding energies \(B_\Lambda \) B Λ ...
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Transjugular Intrahepatic Portosystemic Shunt Creation for Treatment of Gastric Varices: Systematic Literature Review and Meta-Analysis of Clinical Outcomes
To quantify the pooled clinical outcomes of stent-graft transjugular intrahepatic portosystemic shunt (TIPS) creation for the management of gastric varices (GVs) through systematic review of the literature and...
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Open AccessAuthor Correction: Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessRod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease
To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer’s disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-path...
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Learning by supplying and competition threat
This study proposes a model of learning by supplying in an international outsourcing framework, where the supplier of a relationship-specific input can reverse engineer and become a competitor to its partner i...
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Open AccessCytoskeletal disorganization underlies PABPN1-mediated myogenic disability
Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA...
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Item Cold-Start Recommendation with Personalized Feature Selection
The problem of recommending new items to users (often referred to as item cold-start recommendation) remains a challenge due to the absence of users’ past preferences for these items. Item features from side i...
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Open AccessThe therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells
A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability, proliferation, cell cycle progressio...
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Microencapsulation of immunoglobulin Y: optimization with response surface morphology and controlled release during simulated gastrointestinal digestion
Immunoglobulin Y (IgY) is an effective orally administered antibody used to protect against various intestinal pathogens, but which cannot tolerate the acidic gastric environment. In this study, IgY was microe...
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Evaluation of the physico-mechanical properties of activated-carbon enhanced recycled polyethylene/polypropylene 3D printing filament
In this study, recycled polymer feedstocks (high-density polyethylene, HDPE and polypropylene, PP) were added with different percentages of activated carbon (AC) made from coconut fiber waste – 0, 2, 4, 6, and...
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Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence
Human immunodeficiency virus (HIV)-infected patients undergoing antiretroviral therapy are afforded an increased lifespan but also exhibit an elevated incidence of cardiovascular disease. HIV therapy uses a co...
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Open AccessHost immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers
Efficacy and safety are critical concerns when designing drug carriers. Nanoparticles are a particular type of carrier that has gained recent attention in cancer therapeutics.
