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Article
VR-GNN: variational relation vector graph neural network for modeling homophily and heterophily
Graph Neural Networks (GNNs) have achieved remarkable success in diverse real-world applications. Traditional GNNs are designed based on homophily, which leads to poor performance under heterophily scenarios. ...
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Article
Molecular dynamics simulation and experimental study on the effect of surfactants on the compatibility of P(S-DVB)-SO4/CeO2 composite interface
To improve the interfacial compatibility of core–shell composite abrasive composed of sulfate-modified divinylbenzene crosslinked polystyrene P(S-DVB)-SO4) and CeO2, cetyltrimethylammonium bromide (CTAB), sodium ...
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Article
Postnatal nighttime light exposure and infant temperament at age 12 months: mediating role of genus Akkermansia
The gut microbiome has been reported to be associated with nighttime light (NTL) exposure and temperament. However, the specific role of infant gut microbiome plays in NTL exposure and temperament is unclear. ...
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Article
Open AccessThe 50% and 95% effective dose of remimazolam tosilate for anaesthesia induction in sleep disorders patients undergoing laparoscopic cholecystectomy: an up-and-down sequential allocation trial
Previous reports argue that preoperative sleep conditions of patients can influence the dosage of general anaesthesia drugs. Therefore, we aimed to investigate the dose-effect relationship of preoperative slee...
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Article
Open AccessOxophilic Ce single atoms-triggered active sites reverse for superior alkaline hydrogen evolution
The state-of-the-art alkaline hydrogen evolution catalyst of united ruthenium single atoms and small ruthenium nanoparticles has sparked considerable research interest. However, it remains a serious problem th...
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Article
Open AccessOptimization of desert lake information extraction from remote sensing images using cellular automata
Desert lakes are important wetland resources in the blown-sand area of western China and play a significant role in maintaining the regional ecological environment. However, large-scale coal mining in recent y...
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Article
ROS and JA signaling participate in positive regulation of Pyrus betulifolia LysM-containing receptor protein 1 (PbeLYP1) in Valsa canker resistance
Valsa canker, caused by the necrotrophic fungus Valsa species, is one of the most destructive diseases that threatens the development of apple and pear production. The discovery of resistance genes is helpful for...
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Article
Open AccessA robust pipeline for ranking carrier frequencies of autosomal recessive and X-linked Mendelian disorders
Single gene disorders are individually rare but collectively common leading causes of neonatal and pediatric morbidity and mortality. Both parents or the mothers of affected individuals with autosomal recessiv...
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Article
Open AccessThe blood virome of 10,585 individuals from the ChinaMAP
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Article
Open AccessAPI-GNN: attribute preserving oriented interactive graph neural network
Attributed graph embedding aims to learn node representation based on the graph topology and node attributes. The current mainstream GNN-based methods learn the representation of the target node by aggregating...
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Article
Open AccessThe ChinaMAP reference panel for the accurate genotype imputation in Chinese populations
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Article
Open AccessRLINK: Deep reinforcement learning for user identity linkage
User identity linkage is a task of recognizing the identities of the same user across different social networks (SN). Previous works tackle this problem via estimating the pairwise similarity between identitie...
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Article
Correction to: Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells
The article “Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells”, written by “Yaqian Wu, Yanan Cao, Hai**g Liu, Mengfei Yao, Ningning Ma and Bo Zhan...
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Article
Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells
Hypoxia-inducible factors (HIFs) are key mediators expressed under hypoxic condition and involved in many kinds of disease such as cancer and abnormal angiogenesis. Thus, development of their inhibitor has bee...
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Article
Open AccessThe ChinaMAP analytics of deep whole genome sequences in 10,588 individuals
Metabolic diseases are the most common and rapidly growing health issues worldwide. The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders. Th...
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Article
Open AccessSpermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report that spermine synthase (SMS), a ...
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Article
Open AccessComparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
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Article
Open AccessImmune response in piglets orally immunized with recombinant Bacillus subtilis expressing the capsid protein of porcine circovirus type 2
Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome, and is associated with a number of other diseases. PCV2 is widely distributed in most developed swine indu...
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Article
A highly sensitive tetracycline sensor based on a combination of magnetic molecularly imprinted polymer nanoparticles and surface plasmon resonance detection
A method is reported for in-situ detection of the antibiotic tetracycline (TC). It is based on a combination of extraction of TC by magnetic molecularly imprinted polymers nanoparticles (MMIPs NPs) and detecti...
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Article
The nuclear GSK-3β regulated post-transcriptional processing of mRNA through phosphorylation of SC35
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine kinase and regulates a variety of biological processes. Recent studies show GSK-3β can regulate pre-mRNA processing and transcription ...
