8 Result(s)
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Article
Yamina Bennasser
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Article
FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing
In mammals, 2′-O-methylation of RNA is a molecular signature by which the cellular innate immune system distinguishes endogenous from exogenous messenger RNA1–3. However, the molecular functions of RNA 2′-O-methy...
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Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels
Exportin-5 is involved in microRNA precursor nuclear export. Dicer mRNA is now found to compete with pre-miRNAs for exportin-5 binding, suggesting that cytoplasmic levels of Dicer and its pre-miRNA substrate e...
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Open AccessSuppression of HIV-1 replication by microRNA effectors
The rate of HIV-1 gene expression is a key step that determines the kinetics of virus spread and AIDS progression. Viral entry and gene expression were described to be the key determinants for cell permissiven...
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RNAi Therapy for HIV Infection
Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs throu...
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Open AccessHIV-1 Tat interaction with Dicer: requirement for RNA
Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress th...
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Open AccessChanges in microRNA expression profiles in HIV-1-transfected human cells
MicroRNAs (miRNAs) are small RNAs of 18–25 nucleotides (nt) in length that play important roles in regulating a variety of biological processes. Recent studies suggest that cellular miRNAs may serve to control...
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Article
siRNA, miRNA and HIV: promises and challenges
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencin...
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Open AccessHIV-1 encoded candidate micro-RNAs and their cellular targets
MicroRNAs (miRNAs) are small RNAs of 21–25 nucleotides that specifically regulate cellular gene expression at the post-transcriptional level. miRNAs are derived from the maturation by cellular RNases III of im...
