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210 Result(s)
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Article
The minimum feature subset selection problem
In applications of learning from examples to real-world tasks, feature subset selection is important to speed up training and to improve generalization performance. Ideally, an inductive algorithm should use s...
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Article
A tough biodegradable elastomer
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility ...
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Poly(glycerol sebacate)—A Novel Biodegradable Elastomer for Tissue Engineering
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility ...
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Open AccessUnravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
It becomes increasingly clear that our current taxonomy of clinical phenotypes is mixed with molecular heterogeneity. Of vital importance for refined clinical practice and improved intervention strategies is t...
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Experimental Study on the Estrogen-Like Effect of Boric Acid
There are now considerable evidences that boric acid has reproductive and developmental toxicity, but it is uncertain whether such toxicity is caused by estrogen-like effect. Our objective is to determine the ...
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Open AccessIdentification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome
This is a first report, using our MotifModeler informatics program, to simultaneously identify transcription factor (TF) and microRNA (miRNA) binding sites from gene expression microarray data. Based on the assum...
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Article
Experimental study on the estrogen-like effect of mercuric chloride
Although mercuric chloride has toxicity on reproductive system, it is uncertain if such toxicity is induced by estrogen-like effect. To study whether mercuric chloride has the estrogen-like effect and its rele...
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Article
Cardiac tissue engineering using perfusion bioreactor systems
This protocol describes tissue engineering of synchronously contractile cardiac constructs by culturing cardiac cell populations on porous scaffolds (in some cases with an array of channels) and bioreactors wi...
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Open AccessConstructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements
With the advance of large-scale omics technologies, it is now feasible to reversely engineer the underlying genetic networks that describe the complex interplays of molecular elements that lead to complex dise...
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Open AccessTranscription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
Prostate cancer is one of the leading causes of cancer death in men. Androgen ablation, the most commonly-used therapy for progressive prostate cancer, is ineffective once the cancer cells become androgen-inde...
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Article
Open AccessReconstruct gene regulatory network using slice pattern model
Gene expression time series array data has become a useful resource for investigating gene functions and the interactions between genes. However, the gene expression arrays are always mixed with noise, and man...
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Open AccessPrioritization of disease microRNAs through a human phenome-microRNAome network
The identification of disease-related microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment a...
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Article
A proof of the convergence theorem of maximum-entropy clustering algorithm
In this paper, we point out that the counterexample constructed by Yu et al. is incorrect by using scientific computing software Sage. This means that the example cannot negate the convergence theorem of maxim...
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Article
Cenozoic tectonic evolution in the western Qaidam Basin inferred from subsurface data
It is an agreement that collision of Indian and Asian plates causes uplift of the Tibet Plateau. However, great controversy exists about uplifting history and mechanisms of the Tibetan Plateau. Uplift history ...
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Article
Current Density Dependence of Transient Electroluminescence in Phosphorescent Organic Light-Emitting Diodes
The transient electroluminescence (EL) of phosphorescent organic light-emitting diodes (OLEDs) was investigated. The behaviors of the transient characteristics are analyzed using the triplet-triplet annihilati...
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Open AccessA modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer
Estrogens regulate diverse physiological processes in various tissues through genomic and non-genomic mechanisms that result in activation or repression of gene expression. Transcription regulation upon estrog...
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Open AccessChromatin structure characteristics of pre-miRNA genomic sequences
MicroRNAs (miRNAs) are non-coding RNAs with important roles in regulating gene expression. Recent studies indicate that transcription and cleavage of miRNA are coupled, and that chromatin structure may influen...
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Open AccessPrioritizing single-nucleotide variations that potentially regulate alternative splicing
Recent evidence suggests that many complex diseases are caused by genetic variations that play regulatory roles in controlling gene expression. Most genetic studies focus on nonsynonymous variations that can a...
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Article
Open AccessChanges in predicted protein disorder tendency may contribute to disease risk
Recent studies suggest that many proteins or regions of proteins lack 3D structure. Defined as intrinsically disordered proteins, these proteins/peptides are functionally important. Recent advances in next gen...
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Article
Biomarkers of chromosomal damage in peripheral blood lymphocytes induced by polycyclic aromatic hydrocarbons: a meta-analysis
A crucial early event in polycyclic aromatic hydrocarbons (PAHs) carcinogenesis is the induction of genomic instability phenotype that initiates the progression of a proliferative cell into a cancer cell. Howe...