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Article
Open AccessEffects of diets on risks of cancer and the mediating role of metabolites
Research on the association between dietary adherence and cancer risk is limited, particularly concerning overall cancer risk and its underlying mechanisms. Using the UK Biobank data, we prospectively investig...
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Article
Open AccessMulti-omics and single cell characterization of cancer immunosenescence landscape
Cellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored the relationship between cancer senescence signature and telomere le...
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Article
Open AccessRevealing the room temperature superplasticity in bulk recrystallized molybdenum
Body-centered cubic refractory metallic materials exhibit excellent high-temperature strength, but often suffer from brittle intergranular fracture due to the recrystallization-induced enrichment of trace elem...
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Article
Open AccessGenome-wide identification and comprehensive analysis heat shock transcription factor (Hsf) members in asparagus (Asparagus officinalis) at the seeding stage under abiotic stresses
Heat shock transcription factors (Hsf) are pivotal as essential transcription factors. They function as direct transcriptional activators of genes regulated by thermal stress and are closely associated with va...
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Article
Agricultural diversification promotes sustainable and resilient global rice production
Rice is a staple food for half of the human population, but the effects of diversification on yields, economy, biodiversity and ecosystem services have not been synthesized. Here we quantify diversification ef...
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Article
Open AccessFacile fabrication of Eu-based metal–organic frameworks for highly efficient capture of tetracycline hydrochloride from aqueous solutions
The tetracycline hydrochloride (TCH) removal from wastewater is important for the environment and human health yet challenging. Herein, the Eu-based MOF, Eu(BTC) (BTC represents 1,3,5-trimesic acid) was prepar...
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Article
Open AccessImprove the performance of CT-based pneumonia classification via source data reweighting
Pneumonia is a life-threatening disease. Computer tomography (CT) imaging is broadly used for diagnosing pneumonia. To assist radiologists in accurately and efficiently detecting pneumonia from CT scans, many ...
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Article
Open AccessCationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants
Mucosal immunity plays a significant role in the first-line defense against viruses transmitted and infected through the respiratory system, such as SARS-CoV-2. However, the lack of effective and safe adjuvant...
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Open AccessAuthor Correction: Iraq/Afghanistan war lung injury reflects burn pits exposure
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Open AccessHypoxia-associated prognostic markers and competing endogenous RNA coexpression networks in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the most common form of non-small cell lung cancer (NSCLC). Hypoxia has been found in 50–60% of locally advanced solid tumors and is associated with poor prognosis in various tumo...
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Article
Open AccessA self-assembled trimeric protein vaccine induces protective immunity against Omicron variant
The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and immune escape ability, resultin...
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Article
Open AccessIraq/Afghanistan war lung injury reflects burn pits exposure
This descriptive case series retrospectively reviewed medical records from thirty-one previously healthy, war-fighting veterans who self-reported exposure to airborne hazards while serving in Iraq and Afghanis...
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Article
Open AccessConstruction of a new automatic grading system for jaw bone mineral density level based on deep learning using cone beam computed tomography
To develop and verify an automatic classification method using artificial intelligence deep learning to determine the bone mineral density level of the implant site in oral implant surgery from radiographic da...
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Article
Open AccessNext generation sequencing is a highly reliable method to analyze exon 7 deletion of survival motor neuron 1 (SMN1) gene
Spinal muscular atrophy (SMA) is one of the most common and severe genetic diseases. SMA carrier screening is an effective way to identify couples at risk of having affected children. Next-generation sequencin...
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Article
Open AccessBTN2A2 protein negatively regulates T cells to ameliorate collagen-induced arthritis in mice
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by persistent inflammatory responses in target tissues and organs, resulting in the destruction of joints. Collagen type II (CII)-induced arthr...
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Article
Open AccessTEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the development of triple-negative breast cancer (TNBC). Breast tumor-initiating cells (BTICs) are involved in forming VM; howev...
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Article
Open AccessCarbon hollow fiber membranes for a molecular sieve with precise-cutoff ultramicropores for superior hydrogen separation
Carbon molecular sieve (CMS) membranes with rigid and uniform pore structures are ideal candidates for high temperature- and pressure-demanded separations, such as hydrogen purification from the steam methane ...
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Article
Open AccessIdentification and functional characterization of ABCC transporters for Cd tolerance and accumulation in Sedum alfredii Hance
Cd is one of the potential toxic elements (PTEs) exerting great threats on the environment and living organisms and arising extensive attentions worldwide. Sedum alfredii Hance, a Cd hyperaccumulator, is of great...
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Article
Microglia-organized scar-free spinal cord repair in neonatal mice
Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of axons1–4. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar-free healing that permit...
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Open AccessConstruction and analysis for differentially expressed long non-coding RNAs and mRNAs in acute myocardial infarction
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides. Some lncRNAs are related to acute myocardial infarction (AMI) and can serve as blood-based biomarkers for AMI detection. To identify w...