66 Result(s)

Article

UBTF mediates activation of L3MBTL2 to suppress NISCH expression through histone H2AK119 monoubiquitination modification in breast cancer

Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) has been related to transcriptional inhibition and chromatin compaction. Nevertheless, the biological functions and mechanisms of L3MBTL2 are undefined i...

Kun Chen, Yun Dong, Gaojian He, Xuefeng He… in Clinical & Experimental Metastasis (2024)

Article

GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures

Neuroinflammation is being increasingly recognized as a vital factor in the development of various neurological and neuropsychiatric diseases. Lipopolysaccharides (LPS), an outer membrane component of gram-neg...

Xue He, **ao-yi Hu, **ao-yu Yin, **n-miao Wu, Qing-ren Liu… in Neurochemical Research (2024)

Article

Network pharmacology prediction, molecular docking and in vitro experiment explored the potential mechanism of Gaoyuan’an capsule in improving hypoxia tolerance

Tibetan medicine Gaoyuan’an capsule (GYAC) is widely used to prevent pulmonary edema at high altitude, but the specific mechanism has not been explored. In this study, we analyzed the mechanism of GYAC in hypo...

Tianbo **, **aoli Liu, Yuhe Wang, Yi** Qi, Xuemei Li… in The Pharmacogenomics Journal (2024)

Article

Successful Treatment of Refractory EBV-Associated Hemophagocytic Lymphohistiocytosis with Combined Emapalumab and PD-1 Blockade

Yue Song, Weiyang Li, Depei Wu, Xuefeng He, Jianhong Fu in Journal of Clinical Immunology (2024)

Article

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment

Intellectual disability (ID) is a condition characterized by cognitive impairment and difficulties in adaptive functioning. In our research, we identified two de novo mutations (c.955C>T and c.732C>A) at the KDM2...

Zongyao Ren, Haiyan Tang, Wendiao Zhang, Minghui Guo, **gjie Cui… in Neuroscience Bulletin (2023)

Article

Endothelial Cell–Derived Let-7c-Induced TLR7 Activation on Smooth Muscle Cell Mediate Vascular Wall Remodeling in Moyamoya Disease

Moyamoya disease (MMD) is characterized by frequent migration and phenotypic transformation of vascular smooth muscle cells (VSMCs) in the intima layer of blood vessels. However, the underlying mechanism is un...

**aopeng Ma, Yimin Huang, Xuejun He, … in Translational Stroke Research (2023)

Article

Molecular characterization and immunological properties of Echinococcus granulosus sensu stricto (G1) ADK1 and ADK8

Adenylate kinases (ADKs) are one of the important enzymes regulating adenosine triphosphate (ATP) metabolism in Echinococcus granulosus sensu lato. The objective of the present study was to explore the molecular ...

Hong-Yu Song, Jia-Fei Zhan, Rui-Qi Hua, Xue He, **ao-Di Du… in Parasitology Research (2023)

Article

The expression level of Neuronal Calcium Sensor 1 can predict the prognosis of cytogenetically normal AML

Acute myeloid leukemia (AML) is malignant clonal expansion of myeloid blasts with high heterogeneity and numerous molecular biomarkers have been found to judge the prognosis in some specific classifications of...

Weilong Zhang, **g Wang, Wei Li, **aoni Liu, Yali Zhao… in The Pharmacogenomics Journal (2023)

Article

Long Non-Coding RNAs in Retinal Ganglion Cell Apoptosis

Traumatic optic neuropathy or other neurodegenerative diseases, including optic nerve transection, glaucoma, and diabetic retinopathy, can lead to progressive and irreversible visual damage. Long non-coding RN...

Ningzhi Zhang, Wenye Cao, Xuejun He, Yiqiao **ng… in Cellular and Molecular Neurobiology (2023)

Article

Design and Application Strategies of Natural Polymer Biomaterials in Artificial Ovaries

For certain types of cancer patients, ovarian transplantation has a risk of malignant cancer cell infection. However, the autologous transplantation of an artificial ovary is safe and effective, guarantees the...

Xu Peng, Can Cheng, **aomei Zhang, Xueling He, Yan Liu in Annals of Biomedical Engineering (2023)

Article

Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing

Megakaryocytes (MK) are mainly derived from bone marrow and are mainly involved in platelet production. Studies have shown that MK derived from bone marrow may have immune function, and that MK from peripheral...

Weilong Zhang, Changjian Yan, **aoni Liu, ** Yang, **g Wang… in Cancer Gene Therapy (2022)

Article

Bacteroides ovatus-mediated CD27⁻ MAIT cell activation is associated with obesity-related T2D progression

Type 2 diabetes (T2D) is highly associated with obesity. However, the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve aroun...

Yue Li, Yi Yang, ** Wang, Peihong Cai, Mei Li… in Cellular & Molecular Immunology (2022)