113 Result(s)
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Article
Wei** Wen
Life Sciences
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Nuclear translocation of β-catenin and migration of arecoline-induced oral cancer cells reduced by Taiwanin E via p-GSK3β downregulation
Oral squamous cell carcinomas (OSCCs) accounts for 90% of the total oral cancers and is a major public health issue worldwide. It is the most prevalent malignant epithelial neoplasm of the oral cavity.
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Open AccessOliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets
The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleot...
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Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis
Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in man...
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Open AccessIntranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation
Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2 inflammation. However, the underlying mechanism remains uncertai...
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Open AccessSpatio-temporal patterns in the biomass, species composition and nitrogen content of drift macroalgae in an urbanised coastal embayment
Understanding spatio-temporal variability in the production of drift macroalgae is useful for monitoring and assessing the influence of local anthropogenic nutrient sources on coastal ecosystems. In this study...
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Open AccessMetabolomic and genome-wide association studies drive genetic dissection and gene mining in tea plant
As a vital reproductive organ, flowers significantly influence the yield, sensory quality, and breeding efficacy of Camellia sinensis. Many biological characteristics of tea plants are influenced by metabolites; ...
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A zero-inflated model for spatiotemporal count data with extra zeros: application to 1950–2015 tornado data in Kansas
In many tornado climate studies, the number of tornado touchdowns is often the primary outcome of interest. These outcome measures are usually generated under a spatiotemporal correlation structure and contain...
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Initial Upper Palaeolithic material culture by 45,000 years ago at Shiyu in northern China
The geographic expansion of Homo sapiens populations into southeastern Europe occurred by ∼47,000 years ago (∼47 ka), marked by Initial Upper Palaeolithic (IUP) technology. H. sapiens was present in western Siber...
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Open AccessDecoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing
CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively cur...
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Open AccessCircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...
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Open AccessThe dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology
The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount importance in ensuring internal homeostasis and disease progression. Recently, novel subsets of Treg and Th17, namely IL...
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Open AccessThe SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewe...
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Open AccessEnhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
Natural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral blood and cord blood, stem cell-derived NK cells offer an 'off-the-sh...
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Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats
Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri ...
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Open AccessThree-dimensional branch segmentation and phenotype extraction of maize tassel based on deep learning
The morphological structure phenotype of maize tassel plays an important role in plant growth, reproduction, and yield formation. It is an important step in the distinctness, uniformity, and stability (DUS) te...
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Open AccessCharacterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis
Seed oil content is an important agronomic trait of Brassica napus (B. napus), and metabolites are considered as the bridge between genotype and phenotype for physical traits.
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Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions
Diabetic cardiomyopathy is a progressive disease caused by inexplicit mechanisms, and a novel factor, insulin-like growth factor II receptor-α (IGF-IIRα), may contribute to aggravating its pathogenesis. We hyp...
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Open AccessReprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors
Mesenchymal stromal cells (MSCs) have great value in cell therapies. The MSC therapies have many challenges due to its inconsistent potency and limited quantity. Here, we report a strategy to generate induced ...
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Open AccessIntegrating multiomics data accelerates elucidation of plant primary and secondary metabolic pathways
Plants are the most important sources of food for humans, as well as supplying many ingredients that are of great importance for human health. Develo** an understanding of the functional components of plant ...
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Open AccessProximal tubule-derived exosomes contribute to mesangial cell injury in diabetic nephropathy via miR-92a-1-5p transfer
Diabetic nephropathy (DN) is an increasing threat to human health and regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cel...
