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Article
Open AccessThe cost-utility of an intervention for children and adolescents with a parent having a mental illness in the framework of the German health and social care system: a health economic evaluation of a randomized controlled trial
Children of families with a parent with a mental illness have an increased risk of develo** social and mental health problems resulting in decreased quality of life. Therefore, children and adolescents livin...
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Article
Open AccessLAG3 in gastric cancer: it’s complicated
Lymphocyte activation gene 3 (LAG3) is thought to contribute to T cell exhaustion within the tumor microenvironment of solid tumors. This study aimed to analyze the spatial distribution of LAG3 + cells in rela...
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Article
Open AccessStudy protocol of a randomized controlled trial evaluating home treatment with peer support for acute mental health crises (HoPe)
Home treatment (HT) is a treatment modality for patients with severe mental illness (SMI) in acute mental crises. It is frequently considered equivalent to psychiatric inpatient treatment in terms of treatment...
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Article
Open AccessRobotic-assisted minimally invasive Ivor Lewis esophagectomy within the prospective multicenter German da Vinci ** registry trial
Robotic-assisted minimally invasive esophagectomy (RAMIE) has become one standard approach for the operative treatment of esophageal tumors at specialized centers. Here, we report the results of a prospective ...
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Article
Open AccessThe role of migration in mental healthcare: treatment satisfaction and utilization
Migration rates increase globally and require an adaption of national mental health services to the needs of persons with migration background. Therefore, we aimed to identify differences between persons with ...
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Article
Open AccessPredictors of competitive employment in individuals with severe mental illness: results from an observational, cross-sectional study in Germany
Employment is of great importance as it is associated with various positive effects. Individuals with severe mental illness (SMI) are often excluded from competitive employment. Current data on employment of i...
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Article
Open AccessThe evaluation of a physical health promotion intervention for people with severe mental illness receiving community based accommodational support: a mixed-method pilot study
Unhealthy lifestyle constitutes a cause of increased morbidity and mortality in people with severe mental illness. The aim of this mixed-method pilot study was to investigate the feasibility and preliminary ef...
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Article
Open AccessPolygenic risk scores across the extended psychosis spectrum
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of develo** a disorder could guide mitigation measures a...
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Article
Open AccessPrognostic significance of high mobility group A2 (HMGA2) in pancreatic ductal adenocarcinoma: malignant functions of cytoplasmic HMGA2 expression
HMGA2 has frequently been found in benign as well as malignant tumors and a significant association between HMGA2 overexpression and poor survival in different malignancies was described. In pancreatic ductal ...
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Article
Open AccessMulticenter Experience in Robot-Assisted Minimally Invasive Esophagectomy — a Comparison of Hybrid and Totally Robot-Assisted Techniques
Oncological esophageal surgery has evolved significantly in the last decades. From open esophagectomy over (hybrid) minimally invasive surgery, nowadays, robot-assisted minimally invasive esophagectomy (RAMIE)...
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Article
Open AccessDefining benchmarks for robotic-assisted low anterior rectum resection in low-morbid patients: a multicenter analysis
To define the best possible outcomes for robotic-assisted low anterior rectum resection (RLAR) using total mesorectal excision (TME) in low-morbid patients, performed by expert robotic surgeons in German robot...
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Article
Open AccessCriminal victimization, cognitive social capital and mental health in an urban region in Germany: a path analysis
There is ample evidence that experiencing a criminal victimization is associated with lasting emotional problems among victims. To date, the mechanisms behind this association are not well understood. Based on...
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Article
Open AccessEmployment status and desire for work in severe mental illness: results from an observational, cross-sectional study
People with a severe mental illness (SMI) are at particular risk of occupational exclusion. Among the approaches to occupational rehabilitation, supported employment (SE) has been proven to be the most effecti...
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Article
Open AccessInvolvement of medical students in a surgery congress: impact on learning motivation, decision-making for a career in surgery, and educational curriculum
During the preclinical period of medical school, the clinical relevance of theoretical knowledge is given little attention. Medical students of the second year were invited to participate in an interdisciplina...
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Article
Open AccessEffectiveness and cost-effectiveness of a community-based mental health care programme (GBV) for people with severe mental illness in Germany: study protocol for a randomised controlled trial
The community-based mental health care programme GBV is based on the British Community Mental Health Teams and the Dutch Flexible Assertive Community Treatment model. In addition, the programme offers crisis-i...
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Article
Open AccessMental health professionals view about the impact of male gender for the treatment of men with depression - a qualitative study
The underestimation of depression among men may result from atypical depression symptoms and male help-seeking behaviour. However, higher suicide rates among men than among women indicate a need for gender-spe...
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Article
Open AccessThe Impact of Robotics in Learning Roux-en-Y Gastric Bypass: a Retrospective Analysis of 214 Laparoscopic and Robotic Procedures
Proximal Roux-en-Y gastric bypass is commonly used to manage obesity, performed using laparoscopic or robot-assisted minimally invasive surgery. As the prevalence of robotic bariatric surgery increases, furthe...
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Article
Open AccessImplementation of the patient version of the evidence-based (S3) guideline for psychosocial interventions for patients with severe mental illness (IMPPETUS): study protocol for a cluster randomised controlled trial
The German guideline on psychosocial interventions for people with severe mental disorders recommends a broad spectrum of evidence-based treatments. Structured implementation of the associated patient version ...
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Article
Open AccessLethal thrombosis of the iliac artery caused by Aspergillus fumigatus after liver transplantation: case report and review of the literature
Aspergillus fumigatus infections frequently occur after solid organ transplantation. Yet, a fungal thrombosis after liver transplantation is an exceptional finding.
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Article
Open AccessThe genetic relationship between educational attainment and cognitive performance in major psychiatric disorders
Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports a genome-wide polygenic score (GPS) for educational attainment (GPSEDU) can be used to exp...