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Article
Microalbuminuria in Rats Treated with D-Nitroarginine Methyl Ether
Microalbuminuria is an early symptom and prognostic marker of the progression of renal pathology. The analysis of the role of anionic components of the renal glomeruli in the albumin retention and the developm...
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Article
Effect of Neurohypophysial Hormones on Protein Excretion by the Kidneys
Vasopressin (VP) is one of the main factors affecting intraglomerular hemodynamics, filtration pressure, and the state of mesangial cells contributing to proteinuria progression. The aim of this work was to st...
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Article
Role of Proglucagon Peptides in Osmoregulation
Glucagon-like peptide-1 (GLP-1), a product of partial proteolysis of proglucagon, is involved not only in regulation of carbohydrates, but also in water-salt metabolism. The study examined the role of progluca...
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Article
Effect of the Glucagon-like Peptide-1 Mimetic on Ion- and Osmoregulating Renal Functions in Normoglycemia and Hyperglycemia
Incretins are hormones with a wide range of biological activity. We studied the ratio of the glycemic effect of the glucagon-like peptide-1 mimetic and its effect on the renal excretion of sodium and water. It...
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Article
The mechanism of glucagon-like peptide-1 participation in the osmotic homeostasis
We have found the physiological mechanism of intensification of the excessive fluid removal from the body under the action of glucagon-like peptide-1 and its analog exenatide. Under the water load in rats, exe...
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Article
Effects of Selective Agonists of V1a, V2, and V1b Receptors on Sodium Transport in Rat Kidney
The role of subtypes of vasopressin receptors in modulation of renal sodium reabsorption was studied in in vivo experiments on Wistar rats. Selective V1a receptor agonist reduced sodium reabsorption in the kidney...
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Article
The effects of neurohypophysial nonapeptides and their analogs on magnesium excretion in rat kidney
The effects of vertebrate neurohypophysial nonapeptides (vasopressin, vasotocin and their synthesized analogs) on urinary magnesium excretion were studied in rats. Neurohypophysial hormones and their analogs a...
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Article
Correlation of renal solute-free water reabsorption and energy of interaction of vasotocin analogs with V2 receptor
The nonapeptide-receptor interaction energy calculated from docking algorithms was compared with the effect of the same peptides upon solute-free water reabsorption in rat kidney in vivo. Vasotocin and some of...