9 Result(s)
within
Life Sciences
Microbial Genetics and Genomics
Sungho Won
Article
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Article
Fine-scale map** of disease susceptibility locus with Bayesian partition model
The causal relationship between genes and diseases has been investigated with the development of DNA sequence. Polymorphisms incorporated in the HapMap Project have enabled fine map** with linkage disequilib...
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Article
Robust analysis with related samples under the presence of population substructure and its application to body mass index
Recent investigations such as a more powerful quasi-likelihoods score test (MQLS) statistic have enabled the efficient association analysis with related samples. Although those approaches are robust against th...
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Article
Open AccessNetwork analysis for count data with excess zeros
Undirected graphical models or Markov random fields have been a popular class of models for representing conditional dependence relationships between nodes. In particular, Markov networks help us to understand...
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Article
Open AccessBALLI: Bartlett-adjusted likelihood-based linear model approach for identifying differentially expressed genes with RNA-seq data
Transcriptomic profiles can improve our understanding of the phenotypic molecular basis of biological research, and many statistical methods have been proposed to identify differentially expressed genes (DEGs)...
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Article
SNP genotype calling and quality control for multi-batch-based studies
In genetic analyses, the term ‘batch effect’ refers to systematic differences caused by batch heterogeneity. Controlling this unintended effect is the most important step in quality control (QC) processes that...
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Article
Open AccessProgressive effects of single-nucleotide polymorphisms on 16 phenotypic traits based on longitudinal data
There are many research studies have estimated the heritability of phenotypic traits, but few have considered longitudinal changes in several phenotypic traits together.
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Article
missForest with feature selection using binary particle swarm optimization improves the imputation accuracy of continuous data
Missing data are a common problem in large-scale datasets and its appropriate handling is crucial for data analyses. Missingness can be categorized as (1) missing completely at random (MCAR), (2) missing at ra...
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Article
Relative contributions of the host genome, microbiome, and environment to the metabolic profile
Metabolic syndrome is as a well-known risk factor for cardiovascular disease, which is associated with both genetic and environmental factors. Recently, the microbiome composition has been shown to affect the ...
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Article
Rex: R-linked EXcel add-in for statistical analysis of medical and bioinformatics data
Microsoft Excel has substantial functionalities for data management and analyses, and has been the most popular software in this field. However, in spite of Excel’s user-friendly interface and functionality fo...
