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Article
Temperature effect of the induced circular dichroism in the heparin-acridine orange complex
An optical activity was induced in the region of the absorption bands of acridine orange when the dye became bound to heparin. The magnitudes of induced circular dichroism(ICD) increased with increasing polyme...
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Article
Complex formation between copper(II) and poly-N5-(3-hydroxypropyl)-l-glutamine
The complex formed between copper(II) and a polymeric ligand derived from poly-N5-(3-hydroxypropyl)-l-glutamine (PHPG) has been investigated by circular dichroism. It was found that the confonnational changes of ...
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Article
Open AccessImplication of metabolic and dopamine transporter PET in dementia with Lewy bodies
To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB pat...
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Article
Open AccessEffects of Alzheimer’s genetic risk scores and CSF biomarkers in de novo Parkinson’s Disease
Coexisting Alzheimer’s disease (AD) pathology is common in Parkinson’s disease (PD). However, the implications of genetic risk scores (GRS) for AD have not been elucidated in PD. In 413 de novo PD and 195 heal...
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Article
Open AccessSubstantia nigral dopamine transporter uptake in dementia with Lewy bodies
Nigrostriatal dopaminergic degeneration is a pathological hallmark of dementia with Lewy bodies (DLB). To identify the subregional dopamine transporter (DAT) uptake patterns that improve the diagnostic accurac...
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Article
Predictors associated with the rate of progression of nigrostriatal degeneration in Parkinson’s disease
Parkinson’s disease (PD) manifests as a wide variety of clinical phenotypes and its progression varies greatly. However, the factors associated with different disease progression remain largely unknown.