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  1. No Access

    Article

    Identification and functional analysis of multiple murine myeloperoxidase (MPO) promoters and comparison with the human MPO promoter region

    Myeloperoxidase (MPO) is an important component of the oxidative antibacterial defense system of granulocytes. Mammalian MPO gene expression has been most extensively studied in human and murine cells. Transcr...

    W-G Zhao, JP Lu, A Regmi, GE Austin in Leukemia (1997)

  2. No Access

    Article

    Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells

    We have analysed the relationship of the products of two genes, neu and BRCA1, known to be important in human breast cancer. Highly specific antibodies that recognized both the rodent and human form of the BRCA1 ...

    Hong-Tao Zhang, **n Zhang, Hui-Zhen Zhao, Yuri Ka**o, Barbara L Weber… in Oncogene (1997)

  3. No Access

    Article

    2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome

    Idiopathic hypereosinophilic syndrome (HES) is a rare disease with no established effective therapy. It has been reported that interleukin-5 (IL-5) produced by helper T cells plays a major role in the prolifer...

    NT Ueno, S Zhao, LE Robertson, U Consoli, M Andreeff in Leukemia (1997)

  4. No Access

    Article

    AU-rich mRNA instability elements on human papillomavirus type 1 late mRNAs and c-fos mRNAs interact with the same cellular factors

    Expression levels of human papillomavirus type 1 late genes are determined in part by an AU-rich inhibitory sequence in the 3′ untranslated region on the late mRNAs. Fine map** of the AU rich inhibitory sequ...

    Marcus Sokolowski, Cui** Zhao, Wei Tan, Stefan Schwartz in Oncogene (1997)

  5. No Access

    Article

    Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines

    Previous reports suggest that resistance to mitoxantrone in different tumor cell lines is unrelated to the overexpression of p-glycoprotein. In order to determine the role of p-glycoprotein in the cellular pha...

    U Consoli, NT Van, N Neamati, R Mahadevia, M Beran, S Zhao, M Andreeff in Leukemia (1997)

  6. No Access

    Article

    PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium

    Tamoxifen is currently the most widely used drug for the treatment of breast cancer, but there now exists considerable evidence that tamoxifen can also induce endometrial hyperplasia in pre menopausal women. W...

    Yuan Zhao, Stephen Hague, Sanjiv Manek, Lyna Zhang, Roy Bicknell… in Oncogene (1998)

  7. No Access

    Article

    Cloning and characterization of human and mouse telomerase RNA gene promoter sequences

    Variation in telomerase activity is correlated with cellular senescence and tumour progression. However, although the enzymatic activity of telomerase has been well studied, very little is known about how expr...

    Jiang-Qin Zhao, Stacey F Hoare, Robert McFarlane, Sharon Muir… in Oncogene (1998)

  8. No Access

    Article

    Absence of autophosphorylation site Y882 in the p185neu oncogene product correlates with a reduction of transforming potential

    Autophosphorylation of type I receptor tyrosine kinases (RTKs) comprises one step in the signaling events mediated by erbB receptors such as p185neu and EGFR. Previous analysis of p185neu has indicated that there...

    Hong-Tao Zhang, Donald M O'Rourke, Huizhen Zhao, Ramachandran Murali… in Oncogene (1998)

  9. No Access

    Article

    Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression

    We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protei...

    Ji He Zhao, Toshiaki Inoue, Wataru Shoji, Yasuhisa Nemoto, Masuo Obinata in Oncogene (1998)

  10. No Access

    Article

    Benidipine induces thermogenesis in brown adipose tissue by releasing endogenous noradrenaline: a possible mechanism for the anti-obesity effect of calcium antagonists

    BACKGROUND: Anti-obesity effects of calcium antagonists such as benidipine and nifedipine have been described in rodent obesity models, but the mode of action of the calcium antagonists as anti-obesity agents ...

    J Zhao, V Golozoubova, T Bengtsson, B Cannon… in International Journal of Obesity (1999)

  11. No Access

    Article

    Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents

    The aberrant expression of tissue factor (TF) in acute promyelocytic leukemia (APL) cells has been implicated in the pathogenesis of the APL coagulopathy. In this study, we found that in APL patients receiving...

    J Zhu, W-M Guo, Y-Y Yao, W-L Zhao, L Pan, X Cai, B Ju, G-L Sun, H-L Wang… in Leukemia (1999)

  12. No Access

    Article

    Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

    The expression of Bcl-2 family members was examined in normal and leukemic hematopoietic cells. Immature hematopoietic progenitor cells (CD34+/33−/13−) did not express Bcl-2 but Bcl-XL, the majority of CD34 cells...

    M Andreeff, S Jiang, X Zhang, M Konopleva, Z Estrov, VE Snell, Z **e, MF Okcu… in Leukemia (1999)

  13. No Access

    Article

    DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

    Several newly identified tumor suppressor genes including ATM, NBS1, BRCA1 and BRCA2 are involved in DNA double-strand break repair (DSBR) and DNA damage-induced checkpoint activation. Many of the gene products i...

    Gopal K Dasika, Suh-Chin J Lin, Song Zhao, Patrick Sung, Alan Tomkinson… in Oncogene (1999)

  14. No Access

    Article

    PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis

    PSM/SH2-B has been described as a cellular partner of the FcεRI receptor, insulin receptor (IR), insulin-like growth factor-I (IGF-I) receptor (IGF-IR), and nerve growth factor receptor (TrkA). A function has ...

    Heimo Riedel, Nasim Yousaf, Yuyuan Zhao, Dai He**, You** Deng, Jian Wang in Oncogene (2000)

  15. No Access

    Article

    In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

    Somatic mutation of the FLT3 gene, in which the juxtamembrane domain has an internal tandem duplication, is found in 20% of human acute myeloid leukemias and causes constitutive tyrosine phosphorylation of the pr...

    M Zhao, H Kiyoi, Y Yamamoto, M Ito, M Towatari, S Ômura, T Kitamura, R Ueda… in Leukemia (2000)

  16. No Access

    Article

    Expression of a functional inducible nitric oxide synthase in hairy cell leukaemia and ESKOL cell line

    The expression of nitric oxide synthase (NOS) isoforms was investigated in the established ESKOL hairy cell line and in leukemic cells of patients with hairy cell leukemia (HCL). By reverse transcription-polym...

    V Roman, H Zhao, J-M Fourneau, A Marconi, N Dugas, B Dugas, F Sigaux, J-P Kolb in Leukemia (2000)

  17. No Access

    Article

    Single vs twice daily G-CSF dose for peripheral blood stem cells harvest in normal donors and children with non-malignant diseases

    The optimal dose and schedule of G-CSF for mobilization of peripheral blood stem cells (PBSC) is not well defined. G-CSF mobilization was performed in a group of healthy donors and paediatric patients for auto...

    V Lee, CK Li, MMK Shing, KW Chik, K Li, KS Tsang, DC Zhao… in Bone Marrow Transplantation (2000)

  18. No Access

    Article

    Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death

    The hematopoietic cell S/T kinase Pim-1 was originally discovered as a target of murine leukemia provirus integration, and when expressed at increased levels is predisposing to lymphomagenesis. Recently, Pim-1...

    Tony J Pircher, Shuqing Zhao, Justin N Geiger, Bhavana Joneja, Don M Wojchowski in Oncogene (2000)

  19. No Access

    Article

    BRCA1 activation of the GADD45 promoter

    Breast cancer susceptibility gene BRCA1 has been implicated in the control of gene regulation and such regulated genes are thought to mediate the biological role of BRCA1. Overexpression of BRCA1 induces GADD45, ...

    Shunqian **, Hongcheng Zhao, Feiyue Fan, Patricia Blanck, Wenhong Fan… in Oncogene (2000)

  20. No Access

    Article

    Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice

    We have established a panel of nine immortal cell lines from T cell malignancies which arose in mice transgenic for the SCL and LMO1 genes. Cells from the primary malignancies initially grew very slowly in vitro,...

    DS Chervinsky, DH Lam, X-F Zhao, MP Melman, PD Aplan in Leukemia (2001)

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