24 Result(s)
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Article
Rachel Nechushtai
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Open AccessA combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells
Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs. We recently reported that a peptide derived from the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy...
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Open AccessAn anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters
Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the progression of diabetes, negatively impacting insulin production and secretion from pancreatic cells. In search for a tool ...
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Open AccessThe two redox states of the human NEET proteins’ [2Fe–2S] clusters
The NEET proteins constitute a unique class of [2Fe–2S] proteins. The metal ions bind to three cysteines and one histidine. The proteins’ clusters exist in two redox states; the oxidized protein (containing tw...
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Cryo-EM photosystem I structure reveals adaptation mechanisms to extreme high light in Chlorella ohadii
Photosynthesis in deserts is challenging since it requires fast adaptation to rapid night-to-day changes, that is, from dawn’s low light (LL) to extreme high light (HL) intensities during the daytime. To under...
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Open AccessIntegration of photocatalytic and dark-operating catalytic biomimetic transformations through DNA-based constitutional dynamic networks
Nucleic acid-based constitutional dynamic networks (CDNs) have recently emerged as versatile tools to control a variety of catalytic processes. A key challenge in the application of these systems is achieving ...
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Open AccessThe cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans
Programmed cell death, which occurs through a conserved core molecular pathway, is important for fundamental developmental and homeostatic processes. The human iron–sulfur binding protein NAF-1/CISD2 binds to ...
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Open AccessThe unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease
NEET proteins comprise a new class of [2Fe-2S] cluster proteins. In human, three genes encode for NEET proteins: cisd1 encodes mitoNEET (mNT), cisd2 encodes the Nutrient-deprivation autophagy factor-1 (NAF-1) and...
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Open AccessPhylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin
The iron-sulfur (2Fe-2S) binding motif CDGSH appears in many important plant and animal proteins that regulate iron and reactive oxygen metabolism. In human it is found in CISD1-3 proteins involved in diabetes...
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Open AccessPhylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates
NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the “NEET” motif. They are involved in the regulation of iron an...
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Correction: Corrigendum: Assembly of photo-bioelectrochemical cells using photosystem I-functionalized electrodes
Nature Energy 1, 15021 (2016); published 18 January 2016; corrected 28 January 2016. In the version of this Article originally published, an author's name contained a typographical error and should have read S...
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Assembly of photo-bioelectrochemical cells using photosystem I-functionalized electrodes
The design of photo-bioelectrochemical cells based on native photosynthetic reaction centres is attracting substantial recent interest as a means for the conversion of solar light energy into electrical power....
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Photosynthetic reaction center-functionalized electrodes for photo-bioelectrochemical cells
During the last few years, intensive research efforts have been directed toward the application of several highly efficient light-harvesting photosynthetic proteins, including reaction centers (RCs), photosyst...
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Integrated photosystem II-based photo-bioelectrochemical cells
Photosynthesis is a sustainable process that converts light energy into chemical energy. Substantial research efforts are directed towards the application of the photosynthetic reaction centres, photosystems I...
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The carboxyl-terminal region of the spinach PsaD subunit contains information for its specific assembly into plant thylakoids
The assembly of the multi-subunit membrane-protein Photosystem I (PS I) complex involves incorporation of peripheral proteins into the complex. Here we studied assembly of the PsaD subunit of the cyanobacteria...
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Assembly of the chlorophyll-protein complexes
The biogenesis of photosynthetic complexes in plants and algae is a multi-step process that involves intricate coordination of steps in two intracellular compartments, the chloroplast and the cytoplasm. The pr...
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Function and organization of Photosystem I polypeptides
Photosystem I functions as a plastocyanin:ferredoxin oxidoreductase in the thylakoid membranes of chloroplasts and cyanobacteria. The PS I complex contains the photosynthetic pigments, the reaction center P700...
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Stable assembly of PsaE into cyanobacterial photosynthetic membranes is dependent on the presence of other accessory subunits of photosystem I
We studied assembly of the PsaE subunit of photosystem I into photosynthetic membranes of cyanobacterial mutant strains that lack specific photosystem I subunits. Radiolabeled PsaE was incubated with photosynt...
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Subunit III (Psa-F) of photosystem I reaction center of the C4 dicotyledon Flaveria trinervia
An immunological survey of C3, C4 and C3-C4-intermediate Flaveria species showed that subunit III (PsaF) of the photosystem I reaction center (PSI-RC) is present in all these species. This was confirmed by the is...
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The apoprotein precursor of the major light-harvesting complex of photosystem II (LHCIIb) is inserted primarily into stromal lamellae and subsequently migrates to the grana
The formation of the lateral distribution of the major antenna complex of photosystem II (LHCIIb) between the granal and stromal lamellae was studied. Specifically, the localization of the insertion and the as...
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Assembly of the barley light-harvesting chlorophyll a/b proteins in barley etiochloroplasts involves processing of the precursor on thylakoids
A barley gene encoding the major light-harvesting chlorophyll a/b-binding protein (LHCP) has been sequenced and then expressed in vitro to produce a labelled LHCP precursor (pLHCP). When barley etiochloroplasts a...
