34 Result(s)
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Article
R. D. Smith
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Article
Activated ClpP kills persisters and eradicates a chronic biofilm infection
Chronic infections are difficult to treat with antibiotics but are caused primarily by drug-sensitive pathogens. Dormant persister cells that are tolerant to killing by antibiotics are responsible for this app...
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Microwave annealing for preparation of crystalline hydroxyapatite thin films
A sol was spun on single crystal silicon substrates at a spin-rate of 3000–5000 rpm followed by a low temperature cure to form a stable sol–gel/silicon structure. Good quality crystalline HA films of thickness...
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Mechanisms of action of pH-induced effects on vascular smooth muscle
It is clear that pH has many effects on vascular smooth muscle and the overall action of pH on force will depend on the type of vascular smooth muscle in question and the combined effects on all the potential ...
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Membrane Cholesterol Regulates Smooth Muscle Phasic Contraction
The regulation of contractile activity in smooth muscle cells involves rapid discrimination and processing of a multitude of simultaneous signals im**ing on the membrane before an integrated functional respo...
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Nanoscale proteomics
Efforts to develop a liquid chromatography (LC)/mass spectrometry (MS) technology for ultra-sensitive proteomics studies (i.e., nanoscale proteomics) are described. The approach combines high-efficiency nanosc...
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Devolved budgetary responsibility in primary care
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The effect of high energy electrons during the growth of ZnSe and ZnMgSe by molecular beam epitaxy
Electron irradiation during reflection high-energy electron diffraction is shown to affect the growth of ZnSe and ZnMgSe by molecular beam epitaxy. The high-energy electrons produce an electron stimulated deso...
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The effects of changing intracellular pH on calcium and potassium currents in smooth muscle cells from the guinea-pig ureter
Guinea-pig ureteric smooth muscle is unusual in that intracellular acidification increases and alkalinization decreases force production. To help elucidate the mechanism underlying these effects on force we h...
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Variations in Seroprevalence and Host Factors for Bovine Anaplasmosis in Illinois
Hungerford, L.L. and Smith, R.D., 1997. Variations in seroprevalence and host factors for bovine anaplasmosis in Illinois. Veterinary Research Communications, 21 (1), 9-18.
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Generation of voluminous silicic magmas and formation of mid-Cenozoic crust beneath north-central Mexico: evidence from ignimbrites, associated lavas, deep crustal granulites, and mantle pyroxenites
Isotopic and trace element data from mantle and granulite xenoliths are used to estimate the relative contributions of mantle and crustal components to a large ignimbrite, referred to as the upper ignimbrite,...
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Changes of pH affect calcium currents but not outward potassium currents in rat myometrial cells
Spontaneous contraction of uterine smooth muscle is enhanced by alkalinization and depressed by acidification. We have investigated the ionic currents responsible for this in single myometrial cells. Intracell...
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Protein-phosphatase inhibitors block root hair growth and alter cortical cell shape of Arabidopsis roots
Emerging evidence suggests that protein phosphatases play an important role in the growth and development of higher plants. We report here on the effects of okadaic acid and calyculin-A, two specific and poten...
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Trap**, detection and reaction of very large single molecular ions by mass spectrometry
RECENT developments have made electrospray-ionization (ESI) mass spectrometry1–3 an important technique for measuring molecular weights and studying the structures of large molecules of relative molecular masses...
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Nuclear reactions and screened-coulomb fusion rates
We discuss properties of nuclear reactions (branching ratios, reaction constants, etc.) between hydrogen isotopes from the standpoint of recent R-matrix calculation.. Using R-matrix theory to include nuclear e...
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Influence of solid-state CaS-CaO-CaSO4 deposits on corrosion of high-temperature alloys in simulated FBC environments
This study addresses questions concerning the likelihood of sulfidation attack of heat-exchanger alloys beneath deposits of sulfur-sorbent material in fluidized-bed combustors. Alloy specimens were exposed at ...
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β-Methyl carboline, a benzodiazepine inverse agonist, attenuates the effect of triazolam on the circadian rhythm of locomotor activity
The benzodiazepine triazolam, the benzodiazepine inverse agonist, β-methyl carboline (β-CCM) or both, were administered to adult male hamsters under conditions of constant light. When given alone, triazolam in...
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Tolerability of Long Term Therapy with Enalapril Maleate in Patients Resistant to Other Therapies and Intolerant to Captopril
Patients with severe hypertension and/or congestive heart failure (n = 281) who were unresponsive to other therapies and intolerant to captopril received enalapril treatment (mean dose 19.5 mg/day) under study...
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Corrosion of nickel-base and iron-base alloys in a simulated fluidized-bed coal-combustion environment
The modes of initiation and propagation of corrosion attack on a series of high-temperature alloys were studied in synthetic gas mixtures at 900°C. The gas mixtures were intended to simulate the oxygen and sul...
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Effects of anaerobiosis on root metabolism of Zostera marina (eelgrass): implications for survival in reducing sediments
The temperate seagrass Zostera marina L. typically grows in highly reducing sediments. Photosynthesis-mediated O2 supplied to below-ground tissues sustains aerobic respiration during photosynthetic periods. Roots...
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Capillary zone electrophoresis-MS
Coupling the separation capabilities of capillary zone electrophoresis with the analytical specificity of mass spectrometry yields a tool for detecting levels of substances down to 10 attomoles.
