37 Result(s)
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Article
Pengyuan Liu
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A cross-species proteomic map reveals neoteny of human synapse development
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood1,2. Here we generate a cross-species proteomic map of synapse development in the human, macaque and m...
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Open AccessRobustness of single-cell RNA-seq for identifying differentially expressed genes
A common feature of single-cell RNA-seq (scRNA-seq) data is that the number of cells in a cell cluster may vary widely, ranging from a few dozen to several thousand. It is not clear whether scRNA-seq data from...
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Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer
Lacking a precise targeting strategy, castration-resistant prostate cancer (CRPC) is still hard to be treat effectively. Exploring treatment options that can accurately target CPRC is an important issue with u...
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Open AccessTranscriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis
Peritoneal dialysis (PD) is associated with increased cardiovascular (CV) risk. Studies of PD-related CV pathology in animal models are lacking despite the clinical importance. Here we introduce the phenotypic...
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Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model
Persistent pulmonary hypertension of the newborn (PPHN) occurs when pulmonary vascular resistance (PVR) fails to decrease at birth. Decreased angiogenesis in the lung contributes to the persistence of high PVR...
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Open AccessLncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation
Long non-coding RNAs (lncRNAs) play key roles in cancer development and progression. However, the biological function and clinical significance of most lncRNAs in cervical cancer remain elusive. In this study,...
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Molecular diversity and biogeography of benthic microeukaryotes in temperate seagrass (Zostera japonica) systems of northern China
The productivity and health of seagrass depend on the combined inputs of nutrients from the water and sediments in which they grow and the microbiota with which they live intimately. However, little is known a...
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Open AccessLCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis
Long non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro...
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Open AccesscircFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer
CircRNAs are a novel class of evolutionarily conserved noncoding RNA molecules that form covalently closed continuous loop structures without 5′ caps and 3′ poly(A) tails. Accumulating evidence suggests that c...
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Open AccessLong-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a key event in cervical carcinogenesis. Here, we perform comprehensive characterization of large-range virus-human integrati...
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Multi-omics map** of human papillomavirus integration sites illuminates novel cervical cancer target genes
Integration of human papillomavirus (HPV) into the host genome is a dominant feature of invasive cervical cancer (ICC), yet the tumorigenicity of cis genomic changes at integration sites remains largely unders...
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Open AccessLCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC
Long non-coding RNAs (lncRNAs) are important epigenetic regulators, which play critical roles in diverse physiological and pathological processes. However, the regulatory mechanism of lncRNAs in lung carcinoge...
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Open AccessOccupational gender segregation and gendered language in a language without gender: trends, variations, implications for social development in China
This paper proposes a textual analytics approach to the discovery of trends and variations in social development. Specifically, we have designed a linguistic index that measures the marked usage of gendered mo...
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Open AccessNuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells
ErbB2, a classical receptor tyrosine kinase, is frequently overexpressed in breast cancer cells. Although the role of ErbB2 in the transmission of extracellular signals to intracellular matrix has been widely ...
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Open AccessPlasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma
Endometrial cancer (EC) is a major cause of death among gynecologic malignancies. To improve early detection of EC in patients, we carried out a large plasma-derived exosomal microRNA (miRNA) studies for diagn...
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Open AccessAlternative polyadenylation: methods, mechanism, function, and role in cancer
Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a singl...
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Open AccesstRNA-derived RNA fragments in cancer: current status and future perspectives
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekee** ncRNAs t...
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Open AccessProphylactic chemotherapeutic hyperthermic intraperitoneal perfusion reduces peritoneal metastasis in gastric cancer: a retrospective clinical study
Peritoneal metastasis is the most frequent failure in gastric cancer. This study evaluated the role of prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion (CHIP) in patients after D2 dissection.
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Conrad’s F-condition for partially ordered monoids
In this paper, we study Conrad’s F-condition for lattice-ordered monoids, Riesz monoids, and pre-Riesz monoids.
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Unsupervised learning of monocular depth and ego-motion with space–temporal-centroid loss
We propose DPCNN (Depth and Pose Convolutional Network), a novel framework for monocular depth with absolute scale and camera motion estimation from videos. DPCNN uses our proposed stereo training examples, in...
