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Article
A cross-species proteomic map reveals neoteny of human synapse development
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood1,2. Here we generate a cross-species proteomic map of synapse development in the human, macaque and m...
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Article
Open AccessRobustness of single-cell RNA-seq for identifying differentially expressed genes
A common feature of single-cell RNA-seq (scRNA-seq) data is that the number of cells in a cell cluster may vary widely, ranging from a few dozen to several thousand. It is not clear whether scRNA-seq data from...
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Article
Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer
Lacking a precise targeting strategy, castration-resistant prostate cancer (CRPC) is still hard to be treat effectively. Exploring treatment options that can accurately target CPRC is an important issue with u...
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Article
Open AccessTranscriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis
Peritoneal dialysis (PD) is associated with increased cardiovascular (CV) risk. Studies of PD-related CV pathology in animal models are lacking despite the clinical importance. Here we introduce the phenotypic...
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Article
Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model
Persistent pulmonary hypertension of the newborn (PPHN) occurs when pulmonary vascular resistance (PVR) fails to decrease at birth. Decreased angiogenesis in the lung contributes to the persistence of high PVR...
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Chapter and Conference Paper
MSDD: A Multimodal Language Dateset for Stance Detection
Stance Detection is the task of automatically determining whether the author of a text is positive, negative, or neutral towards a given target. Correct detecting stance is conducive to false news detection, c...
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Chapter and Conference Paper
Moral Essential Elements: MEE-A Dataset for Moral Judgement
Moral judgments, including moral polarity judgments, moral intensity judgments, and moral type judgments, are important in hel** people to understand the moral characteristics of behaviors. Moral judgments d...
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Chapter and Conference Paper
CCD-ASQP: A Chinese Cross-Domain Aspect Sentiment Quadruple Prediction Dataset
This work present CCD-ASQP, a cross-domain Aspect Sentiment Quadruple prediction(ASQP) dataset in chinese. Based on e-commerce scenario, this dataset lables 15,878 sentiment quadruples out of 3,700 reviews acr...
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Chapter and Conference Paper
Corpus-Based Lexical Features and Thematic Analysis of CHina’s Five-Year Plan for the 21st Century
The Five-Year Plan is one of the typical symbols and representations of the socialist system with Chinese characteristics, and its interpretation is of far-reaching significance. This paper selects the five Fi...
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Article
Open AccessLncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation
Long non-coding RNAs (lncRNAs) play key roles in cancer development and progression. However, the biological function and clinical significance of most lncRNAs in cervical cancer remain elusive. In this study,...
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Article
Molecular diversity and biogeography of benthic microeukaryotes in temperate seagrass (Zostera japonica) systems of northern China
The productivity and health of seagrass depend on the combined inputs of nutrients from the water and sediments in which they grow and the microbiota with which they live intimately. However, little is known a...
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Article
Open AccessLCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis
Long non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro...
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Article
Open AccesscircFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer
CircRNAs are a novel class of evolutionarily conserved noncoding RNA molecules that form covalently closed continuous loop structures without 5′ caps and 3′ poly(A) tails. Accumulating evidence suggests that c...
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Article
Open AccessLong-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a key event in cervical carcinogenesis. Here, we perform comprehensive characterization of large-range virus-human integrati...
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Chapter and Conference Paper
Ignition Characteristics of Coal/Air Jets from Rectangular Nozzles
The ignition characteristics of pulverized coal-air jets from rectangular nozzles with different aspect ratios (ARs) were studied using a Hencken type entrained flow reactor. High-speed cameras and Mie scatter...
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Chapter and Conference Paper
The Corpus Construction of Basic Noun Compound Phrase in Literature Domain and Its Comparison with News Domain
At present, a relatively large number of knowledge bases that contains semantic relation of noun compound has been established, but there is a lack of comparative research on noun phrases between corpora. This...
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Chapter and Conference Paper
CDAIL-BIAS MEASURER: A Model Ensemble Approach for Dialogue Social Bias Measurement
Dialogue systems based on neural networks trained on large-scale corpora have a variety of practical applications today. However, using uncensored training corpora may have risks, such as potential social bias...
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Article
Multi-omics map** of human papillomavirus integration sites illuminates novel cervical cancer target genes
Integration of human papillomavirus (HPV) into the host genome is a dominant feature of invasive cervical cancer (ICC), yet the tumorigenicity of cis genomic changes at integration sites remains largely unders...
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Article
Open AccessLCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC
Long non-coding RNAs (lncRNAs) are important epigenetic regulators, which play critical roles in diverse physiological and pathological processes. However, the regulatory mechanism of lncRNAs in lung carcinoge...
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Article
Open AccessOccupational gender segregation and gendered language in a language without gender: trends, variations, implications for social development in China
This paper proposes a textual analytics approach to the discovery of trends and variations in social development. Specifically, we have designed a linguistic index that measures the marked usage of gendered mo...
