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Article
Open AccessTranscriptomic characterization of Trichoderma harzianum T34 primed tomato plants: assessment of biocontrol agent induced host specific gene expression and plant growth promotion
In this study, we investigated the intricate interplay between Trichoderma and the tomato genome, focusing on the transcriptional and metabolic changes triggered during the late colonization event. Microarray pro...
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Article
Somatostatin neurons in the central amygdala mediate anxiety by disinhibition of the central sublenticular extended amygdala
Fear and anxiety are two defensive emotional states evoked by threats in the environment. Fear can be initiated by either imminent or future threats, but experimentally, it is typically studied as a phasic res...
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Article
Open AccessLocating causal hubs of memory consolidation in spontaneous brain network in male mice
Memory consolidation after learning involves spontaneous, brain-wide network reorganization during rest and sleep, but how this is achieved is still poorly understood. Current theory suggests that the hippocam...
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Article
Open AccessChanges in pallidal neural activity following long-term symptom improvement from botulinum toxin treatment in DYT6 dystonia: a case report
The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable. In ...
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Article
Open AccessLow-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling
Advanced physiological aging is associated with impaired cognitive performance and the inability to induce long-term potentiation (LTP), an electrophysiological correlate of memory. Here, we demonstrate in the...
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Article
Open AccessSaturated free fatty acids and association with memory formation
Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modula...
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Article
Open AccessA randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder
Deep brain stimulation (DBS) is a promising treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with...
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Article
Open AccessDiversity of interneurons in the lateral and basal amygdala
The basolateral amygdala (BLA) is a temporal lobe structure that contributes to a host of behaviors. In particular, it is a central player in learning about aversive events and thus assigning emotional valence...
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Article
Open Access1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the develo** mouse prefrontal cortex
Schizophrenia has been associated with a range of genetic and environmental risk factors. Here we explored a link between two risk factors that converge on a shared neurobiological pathway. Recent genome-wide ...
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Article
Open AccessSpectral changes associated with transmission of OLED emission through human skin
A recent and emerging application of organic light emitting diodes (OLEDs) is in wearable technologies as they are flexible, stretchable and have uniform illumination over a large area. In such applications, t...
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Article
Neural circuits for a top-down control of fear and extinction
Fear learning and extinction are controlled by the activity of three interconnected regions: the amygdala, hippocampus, and prefrontal cortex. Of these, the medial prefrontal cortex modulates specific aspects ...
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Article
Open AccessThe association between neonatal vitamin D status and risk of schizophrenia
Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophren...
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Article
Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear
In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been ...
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Article
Open AccessElongator mutation in mice induces neurodegeneration and ataxia-like behavior
Cerebellar ataxias are severe neurodegenerative disorders with an early onset and progressive and inexorable course of the disease. Here, we report a single point mutation in the gene encoding Elongator comple...
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Article
Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction
We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal...
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Article
Open AccessThe nature and nurture of education
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Article
Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear
The medial prefrontal cortex (mPFC) has been implicated in the extinction of emotional memories, including conditioned fear. We found that ventral hippocampal (vHPC) projections to the infralimbic (IL) cortex ...
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Article
Open AccessIntegrating neuroscience and learning: now’s the time...
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Article
Correction: Corrigendum: Regulating anxiety with extrasynaptic inhibition
Nat. Neurosci. 18, 1493–1500 (2015); published online 31 August 2015; corrected after print 5 October 2015 In the version of this article initially published, the grant number for U.R. was given as R01MH80006 ...
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Article
Regulating anxiety with extrasynaptic inhibition
Less is known about the role of amygdala circuits in anxiety than in acute fear responses. In this study, the authors demonstrate that aversive experience induces anxiety in mice by regulating the excitability...
